Ramai Daryl, Lai Jonathan, Monzidelis Constantine, Reddy Sarath
1 Department of Medicine, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, Brooklyn, NY, USA.
2 Department of Anatomical Sciences, School of Medicine, St George's University, Grenada, West Indies.
J Cardiovasc Pharmacol Ther. 2018 Jul;23(4):292-300. doi: 10.1177/1074248418769633. Epub 2018 Apr 11.
After thickening of the cardiac chamber walls during embryogenesis, oxygen and nutrients can no longer be adequately supplied to cardiac cells via passive diffusion; therefore, a primitive vascular network develops to supply these vital structures. This plexus further matures into coronary arteries and veins, which ensures continued development of the heart. Various models have been proposed to account for the growth of the coronary arteries. However, lineage-tracing studies in the last decade have identified 3 major sources, namely, the proepicardium, the sinus venosus, and endocardium. Although the exact contribution of each source remains unknown, the emerging model depicts alternative pathways and progenitor cells, which ensure successful coronary angiogenesis. We aim to explore the current trends in coronary artery development, the cellular and molecular signals regulating heart vascularization, and its implications for heart disease and vascular regeneration.
在胚胎发育过程中心腔壁增厚后，氧气和营养物质无法再通过被动扩散充分供应给心肌细胞；因此，一个原始的血管网络发育形成以供应这些重要结构。这个丛状结构进一步成熟为冠状动脉和静脉，从而确保心脏的持续发育。已经提出了各种模型来解释冠状动脉的生长。然而，过去十年的谱系追踪研究已经确定了3个主要来源，即心外膜、静脉窦和心内膜。尽管每个来源的确切贡献尚不清楚，但新出现的模型描绘了确保冠状动脉血管生成成功的替代途径和祖细胞。我们旨在探讨冠状动脉发育的当前趋势、调节心脏血管化的细胞和分子信号及其对心脏病和血管再生的影响。
