Meng Qin, Duan Pengjing, Li Lin, Miao Yongmei
Department of Gynecology and Obstetrics, Shandong Medical College Linyi.
Department of Gynecology and Obstetrics, Affiliated Hospital of Shandong Medical College Linyi.
Tohoku J Exp Med. 2018 Apr;244(4):291-296. doi: 10.1620/tjem.244.291.
Ovarian cancer is the fourth leading cause of cancer death in women and the most fatal gynecologic malignancy. Placenta growth factor (PGF), a member of the vascular endothelial growth factor, plays an important role in angiogenesis. The overexpression of PGF was observed in several types of cancers, but the clinical significance of PGF in epithelial ovarian cancer (EOC) is still unknown. To explore the prognostic value of PGF among patients with serous EOC, we analyzed the expression of PGF in 89 EOC specimens by immunohistochemistry. The scoring system of immunohistochemistry was based on the staining intensity and the percentage of PGF-positive cells in each EOC tissue. According to the immunohistochemical score, 34 patients with score ≥ 6 were defined as high PGF expression, and other 55 patients were the group with low PGF expression. The prognostic significance of PGF expression was analyzed. EOC patients with higher IHC scores of PGF expression are significantly associated with positive lymphatic invasion and poorer response to chemotherapy. Patients with higher IHC scores of PGF expression had poorer response to chemotherapy and lower overall survival rate. Additionally, the positive lymph node metastasis, advanced TNM stage, and poorer response to chemotherapy were all remarkably correlated to poorer prognosis. In conclusion, patients with higher PGF in EOC tissues were more predisposed to positive lymphatic invasion, poorer response to chemotherapy and unfavorable prognosis of patients with serous EOC. We propose that PGF expression may be predictive of chemoresistance and poor prognosis of serous EOC.
卵巢癌是女性癌症死亡的第四大主要原因，也是最致命的妇科恶性肿瘤。胎盘生长因子（PGF）是血管内皮生长因子家族的一员，在血管生成中起重要作用。在几种类型的癌症中都观察到了PGF的过表达，但PGF在上皮性卵巢癌（EOC）中的临床意义仍不清楚。为了探讨PGF在浆液性EOC患者中的预后价值，我们通过免疫组织化学分析了89例EOC标本中PGF的表达。免疫组织化学评分系统基于每个EOC组织中PGF阳性细胞的染色强度和百分比。根据免疫组织化学评分，将评分≥6分的34例患者定义为PGF高表达组，其余55例患者为PGF低表达组。分析了PGF表达的预后意义。PGF表达免疫组化评分较高的EOC患者与阳性淋巴浸润显著相关，对化疗的反应较差。PGF表达免疫组化评分较高的患者对化疗的反应较差，总生存率较低。此外，阳性淋巴结转移、晚期TNM分期以及对化疗的反应较差均与较差的预后显著相关。总之，EOC组织中PGF较高的患者更容易发生阳性淋巴浸润、对化疗反应较差以及浆液性EOC患者的预后不良。我们认为PGF表达可能预测浆液性EOC的化疗耐药性和不良预后。
