Thomas D J, Stocks J, Galton D J, Besser G M
Department of Diabetes, St Bartholomew's Hospital, London, UK.
Diabet Med. 1988 Jan;5(1):85-6. doi: 10.1111/j.1464-5491.1988.tb00948.x.
Two patients with hypertriglyceridaemia which was diagnosed several years before the onset of diabetes are described. In the first case a 54-year-old man presented with hypertriglyceridaemia and normal glucose tolerance. After 4 years he developed severe hypertriglyceridaemia (22 mmol/l) which was first ascribed to poor compliance but soon afterwards diabetes was diagnosed and good blood glucose control minimized the hypertriglyceridaemia. The second patient, a female, aged 27 years, with the polycystic ovarian syndrome, presented with eruptive xanthoma after several years of mild hyperlipidaemia. There was severe hyperlipidaemia (triglyceride 140 mmol/l, cholesterol 42 mmol/l) which required urgent plasmapheresis. Diabetes was diagnosed and treated with insulin at this time but the patient was taking the oral contraceptive pill and also had a deficiency of apolipoprotein CII.
本文描述了两名在糖尿病发病前数年就被诊断为高甘油三酯血症的患者。在第一个病例中，一名54岁男性表现为高甘油三酯血症且糖耐量正常。4年后，他出现了严重的高甘油三酯血症（22毫摩尔/升），最初归因于依从性差，但随后很快被诊断出患有糖尿病，良好的血糖控制使高甘油三酯血症得到了缓解。第二名患者是一名27岁的女性，患有多囊卵巢综合征，在数年的轻度高脂血症后出现了疹性黄瘤。患者存在严重的高脂血症（甘油三酯140毫摩尔/升，胆固醇42毫摩尔/升），需要紧急进行血浆置换。此时患者被诊断出患有糖尿病并接受胰岛素治疗，但该患者正在服用口服避孕药，且存在载脂蛋白CII缺乏症。
