Ma Y D, Huang D, Chen Y F, Jiang H Y, Liu J H, Sun H Q, Li Z H
Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China.
Institute of Microelectronics, National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Peking University, Beijing 100871, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Apr 18;50(2):358-363.
To explore an electrode suitable for wireless portable sleep monitoring equipment and analyze the result of the signals of electrooculogram (EOG) and electroencephalography (EEG) collected by this kind of flexible electrodes.
The flexible electrodes were prepared by microelectromechanical systems (MEMS) technology. This kind of electrodes consisted parylene, chromium, and gold. Parylene, the flexible substrate of this kind of flexible electrodes, was of biocompatibility. Between parylene and gold there was an adhesion layer of chromium, which connected parylene and gold tightly. Then the flexible electrodes were stuck to medical adhesive tape. The electrodes were designed and made into a grid to make sure that the medical adhesive tape could tape on the skin tightly, so that the contact impedance between the electrodes and the skin would be reduced. Then the alternating current impedance of the electrode were tested by the CHI660E electrochemical workstation after the electrode was achieved. To make sure that this kind of electrodes could be used in EOG monitoring, the electrodes were connected to a wireless signal acquisition suite containing special biological signal acquisition and digital processing chip to gather different sites around the eyes and the electrical signals of different directions of the eye movements, then analyzed the signal-to-noise ratio of the EOG. At the end, the Philips A6 polysomnography was used to compare the noise amplitude of the EEG signals collected by the flexible electrode and the gold cup electrode.
The electrodes stuck to the skin tightly, and these electrodes could collect signals that we wanted while the experiment was performed. The alternating current impedance of the flexible electrode was between 4 kΩ and 13 kΩ while with the frequency of alternating current under 100 Hz, most EEG signal frequencies were at this range. The EOG signals collected by the flexible electrodes were in line with the clinical requirements. The noise amplitude of EEG signals collected by the flexible electrodes was lower than that of the electrical signals collected by the gold cup electrodes.
The flexible electrode could be taken into consideration as an alternative electrode for monitoring EOG and EEG signals, and the wireless portable sleep monitoring devices are to be further developed in the future.
探索一种适用于无线便携式睡眠监测设备的电极,并分析这种柔性电极采集到的眼电图(EOG)和脑电图(EEG)信号结果。
采用微机电系统(MEMS)技术制备柔性电极。这种电极由聚对二甲苯、铬和金组成。聚对二甲苯作为这种柔性电极的柔性基底,具有生物相容性。在聚对二甲苯和金之间有一层铬粘附层,它将聚对二甲苯和金紧密连接。然后将柔性电极粘贴到医用胶带上。电极被设计并制成网格状,以确保医用胶带能紧密贴在皮肤上,从而降低电极与皮肤之间的接触阻抗。电极制成后,用CHI660E电化学工作站测试其交流阻抗。为确保这种电极可用于EOG监测,将电极连接到一个包含特殊生物信号采集和数字处理芯片的无线信号采集套件上,以采集眼睛周围不同部位以及不同眼球运动方向的电信号,然后分析EOG的信噪比。最后,用飞利浦A6多导睡眠图仪比较柔性电极和金杯电极采集到的EEG信号的噪声幅度。
电极能紧密贴在皮肤上,在实验过程中这些电极能够采集到我们所需的信号。当交流电流频率低于100Hz时,柔性电极的交流阻抗在4kΩ至13kΩ之间,大多数EEG信号频率处于此范围。柔性电极采集到的EOG信号符合临床要求。柔性电极采集到的EEG信号的噪声幅度低于金杯电极采集到的电信号的噪声幅度。
柔性电极可作为监测EOG和EEG信号的替代电极加以考虑,未来无线便携式睡眠监测设备有待进一步开发。