Anwar Muhammad, Jamal Qamar, Ahmed Waqaruddin
Dr. Muhammad Anwar, M.Phil (Pathology), Department of Pathology, BMSI, Jinnah Post Graduate Medical Centre, Karachi, Pakistan.
Dr. Qamar Jamal, PhD. (Pathology), Department of Pathology, Ziauddin Medical University, Clifton, Karachi, Pakistan.
Pak J Med Sci. 2018 Jan-Feb;34(1):100-105. doi: 10.12669/pjms.341.14361.
To assess the Histological alteration of liver in asymptomatic HCV PCR positive family blood donors.
This is a prospective cross sectional study carried out at Blood Transfusion Services, Clinical & Molecular Laboratory and Pakistan Health Research Council, Jinnah Postgraduate Medical Centre, Karachi from January 2011 to December 2016. One hundred thirteen (113) Anti HCV and HCV RNA positive family blood donors with normal or slightly raised ALT during three consecutive bimonthly visits were included. After taking consent liver biopsy was done to see the histopathological changes in these study participants. The software program SPSS for windows (Ver.19) was utilized for all statistical analysis.
One hundred thirteen blood donors who were Anti HCV and HCV RNA positive were included. Ninety eight were male and 15 Female with a mean age of 32.3±6.94 years. Nineteen (16.8%) had significant inflammation of grade 2-3. Nine (8.0%) had significant fibrosis and steatosis was seen in 65 (57.5%) cases. Cirrhosis or advanced liver disease was not found in this series.
HCV infected individual with normal ALT level having good physical health, without any sign of advanced liver disease on ultrasonography and routine laboratory investigation like AST, Gamma GT, Alkaline Phosphatase, serum albumin, A/G ratio, platelet count and PT, INR might be highly helpful to predict mild or progressive liver disease. Ultimately it reduces the need of liver biopsy, an invasive procedure having significant complications.
评估无症状HCV PCR阳性家庭献血者肝脏的组织学改变。
这是一项前瞻性横断面研究，于2011年1月至2016年12月在卡拉奇真纳研究生医学中心的输血服务部、临床与分子实验室以及巴基斯坦健康研究委员会开展。纳入了113名抗HCV和HCV RNA阳性的家庭献血者，他们在连续三次每两个月的访视期间ALT正常或略有升高。在获得同意后，进行肝活检以观察这些研究参与者的组织病理学变化。所有统计分析均使用Windows版SPSS软件程序（版本19）。
纳入了113名抗HCV和HCV RNA阳性的献血者。其中98名男性，15名女性，平均年龄为32.3±6.94岁。19名（16.8%）有2-3级显著炎症。9名（8.0%）有显著纤维化，65名（5�.5%）病例有脂肪变性。本系列中未发现肝硬化或晚期肝病。
ALT水平正常、身体健康、超声检查及AST、γ-GT、碱性磷酸酶、血清白蛋白、A/G比值、血小板计数和PT、INR等常规实验室检查无任何晚期肝病迹象的HCV感染者，可能对预测轻度或进展性肝病非常有帮助。最终，这减少了肝活检的需求，肝活检是一种有显著并发症的侵入性检查。
