Sirt1 在抑郁症中的作用及可能机制。
Role and Possible Mechanisms of Sirt1 in Depression.
机构信息
National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Department of Neurobiology, Shanxi Medical University, No. 56 Xin Jian South Road, Taiyuan, Shanxi 030001, China.
Department of Environmental Health, Shanxi Medical University, No. 56 Xin Jian South Road, Taiyuan, Shanxi 030001, China.
出版信息
Oxid Med Cell Longev. 2018 Jan 31;2018:8596903. doi: 10.1155/2018/8596903. eCollection 2018.
Depression is a common, devastating illness. Due to complicated causes and limited treatments, depression is still a major problem that plagues the world. Silent information regulator 1 (Sirt1) is a deacetylase at the consumption of NAD and is involved in gene silencing, cell cycle, fat and glucose metabolism, cellular oxidative stress, and senescence. Sirt1 has now become a critical therapeutic target for a number of diseases. Recently, a genetic study has received considerable attention for depression and found that Sirt1 is a potential gene target. In this short review article, we attempt to present an up-to-date knowledge of depression and Sirt1 of the sirtuin family, describe the different effects of Sirt1 on depression, and further discuss possible mechanisms of Sirt1 including glial activation, neurogenesis, circadian control, and potential signaling molecules. Thus, it will open a new avenue for clinical treatment of depression.
抑郁症是一种常见的、具有破坏性的疾病。由于其病因复杂，治疗方法有限，抑郁症仍然是困扰世界的一个主要问题。沉默信息调节因子 1（Sirt1）是 NAD 消耗的去乙酰化酶，参与基因沉默、细胞周期、脂肪和葡萄糖代谢、细胞氧化应激和衰老。Sirt1 现已成为许多疾病的关键治疗靶点。最近，一项针对抑郁症的遗传研究引起了广泛关注，发现 Sirt1 是一个潜在的基因靶点。在这篇简短的综述文章中，我们试图呈现最新的抑郁症和 Sirtuin 家族的 Sirt1 知识，描述 Sirt1 对抑郁症的不同影响，并进一步讨论 Sirt1 的可能机制，包括神经胶质细胞激活、神经发生、昼夜节律控制和潜在的信号分子。因此，这将为抑郁症的临床治疗开辟新的途径。
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