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致心律失常性二尖瓣脱垂中左心室结构与纤维化的机制性见解

Mechanistic insights of the left ventricle structure and fibrosis in the arrhythmogenic mitral valve prolapse.

作者信息

Fernández-Friera Leticia, Salguero Rafael, Vannini Luca, Argüelles Ana Fidalgo, Arribas Fernando, Solís Jorge

机构信息

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

HM Hospitales-Centro Integral de Enfermedades Cardiovasculares HM-CIEC, Madrid, Spain.

出版信息

Glob Cardiol Sci Pract. 2018 Mar 14;2018(1):4. doi: 10.21542/gcsp.2018.4.

DOI:10.21542/gcsp.2018.4
PMID:29644231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5857061/
Abstract

Mitral valve prolapse (MVP) is a common and benign condition. However, some anatomic forms have been recently associated with life-threatening ventricular arrhythmias and sudden cardiac death. Imaging MVP holds the promise of individualized MVP risk assessment. Noninvasive imaging techniques available today are playing an increasingly important role in the diagnosis, prognosis and monitoring of MVP. In this article, we will review the current evidence on arrhythmogenic MVP, with special focus on the utility of echocardiography and CMR for identifying benign and "malignant" forms of MVP. The clinical relevance of this manuscript lies in the value of imaging technology to improve MVP risk prediction, including those arrhythmic-MVP cases with a higher risk of sudden cardiac death.

摘要

二尖瓣脱垂(MVP)是一种常见的良性病症。然而,最近一些解剖学形式已被发现与危及生命的室性心律失常和心源性猝死有关。对MVP进行成像有望实现个性化的MVP风险评估。当今可用的非侵入性成像技术在MVP的诊断、预后和监测中发挥着越来越重要的作用。在本文中,我们将回顾关于致心律失常性MVP的现有证据,特别关注超声心动图和心脏磁共振成像(CMR)在识别MVP的良性和“恶性”形式方面的效用。本手稿的临床意义在于成像技术在改善MVP风险预测方面的价值,包括那些具有较高心源性猝死风险的心律失常性MVP病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/d2ce7d75c4cd/gcsp-2018-1-e201804-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/086684032ce3/gcsp-2018-1-e201804-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/d8d5007854d9/gcsp-2018-1-e201804-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/abed00f4702a/gcsp-2018-1-e201804-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/3354c7aaac5e/gcsp-2018-1-e201804-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/f27f5ec97ad1/gcsp-2018-1-e201804-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/b56f444e7bb3/gcsp-2018-1-e201804-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/d2ce7d75c4cd/gcsp-2018-1-e201804-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/086684032ce3/gcsp-2018-1-e201804-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/d8d5007854d9/gcsp-2018-1-e201804-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/abed00f4702a/gcsp-2018-1-e201804-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/3354c7aaac5e/gcsp-2018-1-e201804-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/f27f5ec97ad1/gcsp-2018-1-e201804-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/b56f444e7bb3/gcsp-2018-1-e201804-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/471c/5857061/d2ce7d75c4cd/gcsp-2018-1-e201804-g007.jpg

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本文引用的文献

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J Cardiovasc Dev Dis. 2015 Jul 10;2(3):165-175. doi: 10.3390/jcdd2030165.
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T mapping in cardiac MRI.心脏磁共振成像中的T映射
Heart Fail Rev. 2017 Jul;22(4):415-430. doi: 10.1007/s10741-017-9627-2.
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Prolapse Volume to Prolapse Height Ratio for Differentiating Barlow's Disease From Fibroelastic Deficiency.脱垂容积与脱垂高度比值鉴别巴洛病与纤维弹性缺失。
二尖瓣脱垂治疗的研究机会:美国心脏病学会专家小组。
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Malignant Mitral Valve Prolapse: Risk and Prevention of Sudden Cardiac Death.恶性二尖瓣脱垂:心脏性猝死的风险与预防
Curr Treat Options Cardiovasc Med. 2022 May;24(5):61-86. doi: 10.1007/s11936-022-00956-3. Epub 2022 Mar 22.
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