Nieto-González Juan Carlos, Ovalles-Bonilla Juan G, Estrada Eduardo, Serrano-Benavente Belén, Martínez-Barrio Julia, González-Fernández Carlos M, González-Benítez Roberto, Vergara Dangond Cristina, Monteagudo Indalecio, Collado Yurrita Luis, Naredo Esperanza, López-Longo Francisco Javier
Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Department of Psychology, University of California, Davis, CA, USA.
J Int Med Res. 2020 Jan;48(1):300060518767031. doi: 10.1177/0300060518767031. Epub 2018 Apr 12.
Salivary gland ultrasound (SGU) is a reliable technique for assessing the salivary glands in patients with primary Sjögren’s syndrome (pSS). The aim of this study was to elucidate the relationship between SGU findings and autoimmunity in patients with pSS.
Patients with pSS underwent an SGU assessment. The patients were classified into three groups according to their autoimmunity profile: the complete positive group (positive rheumatoid factor, antinuclear antibodies, and anti-Ro/anti-La antibodies), the partial seropositive group (positivity of at least one autoantibody but not all), and the seronegative group.
In total, 93 patients were evaluated. Eighty-six (92.5%) were female, and their median age was 49.5 years. The median disease duration was 12.3 years. Pathological SGU findings were present in 32 (34.4%) patients [25 of 36 (78.1%) in the complete positive group and 7 of 44 (21.9%) in the partial positive group]. Patients with pathological SGU findings had a shorter disease duration and slightly higher European League Against Rheumatism Sjögren’s syndrome disease activity index.
The autoimmunity profile and pathological SGU findings are strongly associated with each other in patients with pSS. However, the disease duration does not seem to be related to pathological SGU findings.
唾液腺超声（SGU）是评估原发性干燥综合征（pSS）患者唾液腺的可靠技术。本研究旨在阐明pSS患者的SGU检查结果与自身免疫之间的关系。
对pSS患者进行SGU评估。根据自身免疫特征将患者分为三组：完全阳性组（类风湿因子、抗核抗体及抗Ro/抗La抗体均为阳性）、部分血清学阳性组（至少一种自身抗体阳性但并非全部阳性）和血清学阴性组。
共评估了93例患者。其中86例（92.5%）为女性，中位年龄为49.5岁。中位病程为12.3年。32例（34.4%）患者出现病理性SGU检查结果[完全阳性组36例中有25例（78.1%），部分阳性组44例中有7例（21.9%）]。出现病理性SGU检查结果的患者病程较短，欧洲抗风湿病联盟干燥综合征疾病活动指数略高。
pSS患者的自身免疫特征与病理性SGU检查结果密切相关。然而，病程似乎与病理性SGU检查结果无关。
