Dong Xichang, Kita Yuji, Oestreich Martin
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623, Berlin, Germany.
Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10728-10731. doi: 10.1002/anie.201802947. Epub 2018 Apr 23.
A catalyst-controlled enantioselective alcohol silylation by Cu-H-catalyzed dehydrogenative Si-O coupling of hydroxy groups α to an oxime ether and simple hydrosilanes is reported. The selectivity factors reached in this kinetic resolution are generally high (s≈50), and these reactions thereby provide reliable access to highly enantioenriched α-hydroxy-substituted oxime ethers. The synthetic usefulness of these compounds is also demonstrated.
报道了一种通过铜-氢催化的肟醚α位羟基与简单硅烷的脱氢硅-氧偶联实现的催化剂控制的对映选择性醇硅烷化反应。该动力学拆分中达到的选择性因子通常较高（s≈50），因此这些反应为获得高度对映体富集的α-羟基取代肟醚提供了可靠的途径。还展示了这些化合物的合成实用性。
