Gonzalez-Ruiz Abraham, Camacho-Lopez Miguel A, Flores-Merino Miriam V
J Nanosci Nanotechnol. 2017 Apr;17(4):2374-381. doi: 10.1166/jnn.2017.12709.
Nanocomposites are materials with unique properties and a wide range of applications. The combination of different nanostructures with traditional materials gives a variety of possibilities that should be analyzed. Especially, functional fluorescent semiconductor quantum dots (QDs) embedded in polymeric matrices have shown promising fluorescence and biocompatibility properties. These hybrid materials can be used in medical applications such as biodiagnostic and bioimaging. In this study, two hydrogels, one of polyethylene glycol diacrylate (PEGDA) and other of polyacrylamide (PAAm), were prepared with quantum dots of CdTe (4 nm of diameter) and characterized. The aim of this research was to analyze the optical properties of the nanocomposites and their cell viability. QDs nanocomposites were fabricated by a free radical polymerization process. The optical studies showed that the nanocomposites have well defined properties of fluorescence. To study the biocompatibility of the nanocomposites, metastatic B16f10 cell line were used and MTT assay was performed. The nanocomposites had a significant improved cell viability compared with QDs solutions.
纳米复合材料是具有独特性能和广泛应用的材料。不同纳米结构与传统材料的结合提供了多种需要分析的可能性。特别是，嵌入聚合物基质中的功能性荧光半导体量子点（QDs）已显示出有前景的荧光和生物相容性特性。这些杂化材料可用于生物诊断和生物成像等医学应用。在本研究中，制备了两种水凝胶，一种是聚乙二醇二丙烯酸酯（PEGDA），另一种是聚丙烯酰胺（PAAm），并对其进行了碲化镉量子点（直径4纳米）的表征。本研究的目的是分析纳米复合材料的光学性质及其细胞活力。量子点纳米复合材料通过自由基聚合过程制备。光学研究表明，纳米复合材料具有明确的荧光性质。为了研究纳米复合材料的生物相容性，使用了转移性B16f10细胞系并进行了MTT测定。与量子点溶液相比，纳米复合材料的细胞活力有显著提高。
