College of Material Science and Engineering , Nanjing Tech University , Nanjing 210009 , China.
Brain Hospital , Affiliated Hospital of Xuzhou Medical University , Xuzhou 221002 , China.
ACS Appl Mater Interfaces. 2018 May 2;10(17):15001-15011. doi: 10.1021/acsami.7b19797. Epub 2018 Apr 19.
By overcoming drug resistance and subsequently enhancing the treatment, the combination therapy of photodynamic therapy (PDT) and chemotherapy has promising potential for cancer treatment. However, the major challenge is how to establish an advanced nanoplatform that can be efficiently guided to tumor sites and can then stably release both chemotherapy drugs and a photosensitizer simultaneously and precisely. In this study, which considered the possibility and targeting efficiency of a magnetic targeting strategy, a novel FeO@mSiO(DOX)@HSA(Ce6) nanoplatform was successfully built; this platform could be employed as an efficient synergistic antitumor nanoplatform with magnetic guidance for highly specific targeting and retention. Doxorubicin (DOX) molecules were loaded into mesoporous silica with high loading capability, and the mesoporous channels were blocked by a polydopamine coating. Human serum albumin (HSA) was conjugated to the outer surface to increase the biocompatibility and blood circulation time, as well as to provide a vehicle for loading photosensitizer chlorin e6 (Ce6). The sustained release of DOX under acidic conditions and the PDT induced by red light exerted a synergistic inhibitory effect on glioma cells. Our experiments demonstrated that the pH-responsive FeO@mSiO(DOX)@HSA(Ce6) nanoplatform was guided to the tumor region by magnetic targeting and that the nanoplatform suppressed glioma tumor growth efficiently, implying that the system is a highly promising photodynamic therapy/chemotherapy combination nanoplatform with synergistic effects for cancer treatment.
通过克服耐药性并随后增强治疗效果，光动力疗法（PDT）和化学疗法的联合治疗在癌症治疗方面具有很大的潜力。然而，主要的挑战是如何建立一种先进的纳米平台，能够有效地引导到肿瘤部位，并且能够稳定地同时精确地释放化疗药物和光敏剂。在本研究中，考虑了磁靶向策略的可能性和靶向效率，成功构建了一种新型的 FeO@mSiO(DOX)@HSA(Ce6)纳米平台；该平台可用作具有磁导向的高效协同抗肿瘤纳米平台，具有高度特异性靶向和保留能力。阿霉素（DOX）分子以高负载能力载入介孔硅中，并通过聚多巴胺涂层阻塞介孔通道。人血清白蛋白（HSA）被连接到外表面以增加生物相容性和血液循环时间，并提供负载光敏剂氯代苝 6（Ce6）的载体。在酸性条件下 DOX 的持续释放和红光诱导的 PDT 对神经胶质瘤细胞产生协同抑制作用。我们的实验表明，pH 响应性 FeO@mSiO(DOX)@HSA(Ce6)纳米平台通过磁靶向引导到肿瘤区域，并有效地抑制了神经胶质瘤肿瘤的生长，这表明该系统是一种具有协同作用的用于癌症治疗的很有前途的光动力疗法/化学疗法联合纳米平台。
