School of Human Sciences (Exercise and Sport Science), The University of Western Australia , Crawley, Western Australia.
School of Biomedical Sciences, The University of Western Australia , Crawley, Western Australia.
J Appl Physiol (1985). 2018 Aug 1;125(2):401-408. doi: 10.1152/japplphysiol.00079.2018. Epub 2018 Apr 12.
Platelet activation, including the formation of monocyte platelet aggregates (MPAs), contributes to atherosclerosis, thrombus formation, and acute coronary syndromes. Regular participation in exercise can lower cardiovascular risk, but little is known regarding the impact of exercise training on platelet function. We investigated the effect of 6 mo of walking exercise on platelet function in sedentary older adults without significant cardiovascular disease. Twenty-seven participants were randomly allocated to 6 mo of either: no-exercise ( n = 13) or 3 × 50 min/wk of supervised center-based walking ( n = 14). Circulating and agonist-induced MPAs were assessed using flow cytometry before [ month 0 (0M)] and after [ month 6 (6M)] the intervention. Circulating MPAs increased from 0M (3.7 ± 1.0%) to 6M (4.7 ± 1.6%) in the no-exercise group ( P = 0.009), whereas a nonsignificant decrease was observed in the walking group (0M 4.3 ± 1.7 vs. 6M 3.7 ± 1.2 %, P = 0.052). The change in MPAs between groups was significant ( P = 0.001). There were no differences between groups in platelet responses to agonists across the interventions (all P > 0.05). Collectively, these data suggest that the absence of regular exercise may increase MPAs, which are cellular mediators involved in atherosclerosis, while regular walking inhibits such increases. The thrombotic function of platelets appears to be relatively unaltered by exercise training. This study provides novel data related to the cardioprotective effects associated with participation in exercise. NEW & NOTEWORTHY Monocyte-platelet aggregates contribute to atherosclerosis and exercise can lower cardiovascular risk. This is the first study to discover that a lack of regular physical activity is associated with increased monocyte-platelet aggregates over a 6-mo intervention period. In contrast, walking exercise inhibits increased monocyte-platelet aggregates in the circulation. This study highlights a novel pathway by which regular participation in exercise exerts its cardioprotective effects.
血小板激活，包括单核细胞血小板聚集物（MPA）的形成，会导致动脉粥样硬化、血栓形成和急性冠状动脉综合征。经常参加运动可以降低心血管风险，但对于运动训练对血小板功能的影响知之甚少。我们研究了 6 个月步行运动对无明显心血管疾病的久坐老年人群血小板功能的影响。27 名参与者被随机分为 6 个月：不运动（n=13）或 3×50 分钟/周监督中心步行（n=14）。在干预前[第 0 个月（0M）]和干预后[第 6 个月（6M）]使用流式细胞术评估循环和激动剂诱导的 MPA。在不运动组，循环 MPA 从 0M（3.7±1.0%）增加到 6M（4.7±1.6%）（P=0.009），而在步行组观察到非显著下降（0M 4.3±1.7 与 6M 3.7±1.2%，P=0.052）。组间 MPA 的变化具有显著性差异（P=0.001）。整个干预过程中，各组对激动剂的血小板反应无差异（所有 P>0.05）。总的来说，这些数据表明，缺乏有规律的运动可能会增加单核细胞血小板聚集物，这是参与动脉粥样硬化的细胞介质，而有规律的步行则抑制这种增加。血小板的血栓形成功能似乎相对不受运动训练的影响。这项研究提供了与运动参与相关的心脏保护作用的新数据。新的和值得注意的：单核细胞-血小板聚集物参与动脉粥样硬化，运动可以降低心血管风险。这是第一项发现，在 6 个月的干预期间，缺乏有规律的体育活动与循环中单核细胞-血小板聚集物的增加有关。相比之下，步行运动抑制了循环中单核细胞-血小板聚集物的增加。这项研究强调了有规律的运动发挥其心脏保护作用的一个新途径。
