Małkowska Anna, Szutowski Mirosław, Dyr Wanda, Bamburowicz-Klimkowska Magdalena
Acta Pol Pharm. 2016 Jul;73(4):1067-1072.
Ethyl glucuronide (EtG) is a direct ethanol metabolite. The presence of EtG in urine can be used as a laboratory test to detect recent alcohol consumption. Several earlier studies in humans and in rats revealed that the same amount of ethanol ingested at different concentrations results in different blood ethanol concen- trations. The effect of different concentrations of ingested ethanol on the resulting EtG levels in urine was tested in WHP rats. The EtG concentration was also measured in rat hair. A significant (p < 0.05) decrease in the total amount of urine EtG after administration of the higher concentration (50%) ethanol solution as compared to 30% ethanol at the same dose of ethanol (3 g/kg) was observed. Median EtG concentration in rat hair of 1.5 ng/mg (range: 0.7-2.3 ng/mg) was observed. Our results demonstrate that EtG production and excretion in WHP rats is dependent on alcohol concentration administered orally. EtG levels in hair closely reflect the fate of EtG in the rat.
葡萄糖醛酸乙酯（EtG）是乙醇的直接代谢产物。尿液中EtG的存在可作为一种实验室检测手段来检测近期的酒精摄入情况。早期的多项人体和大鼠研究表明，摄入相同量但浓度不同的乙醇会导致不同的血液乙醇浓度。在WHP大鼠中测试了不同浓度摄入乙醇对尿液中EtG水平的影响。还测量了大鼠毛发中的EtG浓度。在相同乙醇剂量（3 g/kg）下，与30%乙醇相比，给予较高浓度（50%）乙醇溶液后，尿液中EtG总量显著降低（p < 0.05）。观察到大鼠毛发中EtG的中位浓度为1.5 ng/mg（范围：0.7 - 2.3 ng/mg）。我们的结果表明，WHP大鼠中EtG的产生和排泄取决于口服给予的酒精浓度。毛发中的EtG水平密切反映了大鼠体内EtG的情况。
