Knight K R, Martin T J, Coe S A, O'Brien B M
Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Australia.
Br J Plast Surg. 1988 Mar;41(2):147-9. doi: 10.1016/0007-1226(88)90041-0.
A neuropeptide known as calcitonin gene-related peptide (CGRP) has been shown to have vasodilatory properties in the rabbit epigastric island flap of almost equivalent potency to prostacyclin. The latter is currently regarded as the most potent vasodilator yet to be isolated. CGRP, with its longer-lasting effect in blood and its ability to overcome noradrenaline-induced vasospasm, may be promising for use during or after ischaemic flap transfer or replantation. Another known vasodilatory peptide, atriopeptin, was not as potent in the microvascular bed of the cutaneous flap as in major blood vessels.
一种名为降钙素基因相关肽（CGRP）的神经肽已被证明在兔腹壁岛状皮瓣中具有血管舒张特性，其效力与前列环素几乎相当。前列环素目前被认为是迄今分离出的最有效的血管舒张剂。CGRP在血液中的作用持续时间更长，并且能够克服去甲肾上腺素引起的血管痉挛，在缺血性皮瓣转移或再植手术期间或之后使用可能很有前景。另一种已知的血管舒张肽心房肽，在皮瓣微血管床中的效力不如在主要血管中强。
