Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
PLoS One. 2018 Apr 12;13(4):e0195563. doi: 10.1371/journal.pone.0195563. eCollection 2018.
To investigate the association between oral fluoroquinolones (FQ) and the risk of rhegmatogenous retinal detachment (RRD) using a nationwide population-based study in Korea, designed to control for time-related bias.
As a nested case-control study within a cohort, the KNHIS-NSC 2002-2013 (Korean National Health Insurance Service National Sample Cohort) data used for the investigation. The subjects who visited an ophthalmologist were included in a cohort. Subjects with infectious ocular diseases, severe ocular trauma, and congenital diseases were excluded. Within the cohort, subjects who underwent surgery for RRD were defined as cases, and controls were matched by age group, sex, and cohort entry date using an incidence density sampling method. After investigating the exposure to oral FQ, the odds ratio was calculated by the FQ exposure rate of both groups and adjusted by the confounding factors of demography, health service utilization, and comorbidities.
A total of 1,151 subjects in the case group and 11,470 subjects in the control group were included. There were intergroup differences in household income, numbers of ophthalmologic visits and drug prescriptions, events of intraocular surgeries, and prevalence of diabetes and degenerative myopia (all P's<0.05). The crude odds ratio of the total group was 1.06 (P = 0.53, 95% CI 0.88-1.28), and the odds ratio adjusted for all pre-defined confounders was 1.00 (P = 0.99, 95% CI 0.81-1.24). The crude and adjusted odds ratios were not showed statistical significance (all P's>0.05).
By the nested case-control design, this study showed that oral administration of FQ was not associated with the increased risk of development of RRD.
通过在韩国进行的一项全国性基于人群的研究，调查口服氟喹诺酮（FQ）与孔源性视网膜脱离（RRD）风险之间的关联，该研究旨在控制时间相关偏倚。
作为队列内嵌套病例对照研究，使用 KNHIS-NSC 2002-2013（韩国国家健康保险服务国家抽样队列）数据进行调查。纳入曾就诊于眼科医生的受试者。排除患有传染性眼病、严重眼外伤和先天性疾病的受试者。在队列内，接受 RRD 手术的受试者被定义为病例，并且通过发病率密度抽样方法按年龄组、性别和队列入组日期与对照组相匹配。在调查口服 FQ 的暴露情况后，通过两组的 FQ 暴露率计算比值比，并通过人口统计学、卫生服务利用和合并症的混杂因素进行调整。
共纳入 1151 例病例组和 11470 例对照组受试者。两组在家庭收入、眼科就诊次数和药物处方数量、眼内手术事件以及糖尿病和退行性近视的患病率方面存在差异（均 P<0.05）。总人群的粗比值比为 1.06（P=0.53，95%CI 0.88-1.28），经所有预先定义的混杂因素调整后的比值比为 1.00（P=0.99，95%CI 0.81-1.24）。粗比值比和调整比值比均无统计学意义（均 P>0.05）。
通过嵌套病例对照设计，本研究表明口服 FQ 与 RRD 发病风险增加无关。
