通过两种离子金属配合物之间的高效能量转移增强软盐的单线态氧生成。
Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes.
作者信息
Ma Yun, Zhang Shujun, Wei Huanjie, Dong Yafang, Shen Liang, Liu Shujuan, Zhao Qiang, Liu Li, Wong Wai-Yeung
机构信息
Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NJUPT), 9 Wenyuan Road, Nanjing 210023, Jiangsu, P. R. China.
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, School of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, Hubei, P. R. China.
出版信息
Dalton Trans. 2018 Apr 24;47(16):5582-5588. doi: 10.1039/c8dt00720a.
In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(iii) complex [Ir(L)(L')]3+(PF6-)3 (C1) with L and L' being terpyridine ligands (L = 4'-phenyl-2,2':6',2''-terpyridine, L' = 3-([2,2':6',2''-terpyridin]-4'-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(iii) complex [Ir(dfppy)2CN2]-Bu4N+ (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes. Furthermore, this novel photosensitizer was successfully applied in photodynamic therapy (PDT) of cancer cells for the first time.
在本研究中，已开发出一种基于软盐配合物的光敏剂用于癌细胞的光动力疗法（PDT）。选择铱（III）配合物[Ir（L）（L'）]3 +（PF6 -）3（C1），其中L和L'为三联吡啶配体（L = 4'-苯基-2,2':6',2''-三联吡啶，L' = 3 -（[2,2':6',2''-三联吡啶]-4'-基）-9-己基-9H-咔唑）作为阳离子组分，并选择铱（III）配合物[Ir（dfppy）2CN2]-Bu4N +（A1）作为阴离子组分。配合物C1和A1通过静电相互作用直接连接形成基于软盐的光敏剂（S1），由于两种离子金属配合物之间的有效能量转移，其单线态氧生成速率提高。此外，这种新型光敏剂首次成功应用于癌细胞的光动力疗法（PDT）。
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