Laboratoire des Interactions Epithéliums Neurones, Université Bretagne Loire (UBL), UFR Sciences et Techniques, 6 Av. Victor Le Gorgeu, CS93837, 29238, Brest Cedex 3, France.
Laboratoire des Interactions Epithéliums Neurones, Université Bretagne Loire (UBL), UFR Sciences et Techniques, 6 Av. Victor Le Gorgeu, CS93837, 29238, Brest Cedex 3, France.
Food Chem Toxicol. 2018 Jun;116(Pt B):77-85. doi: 10.1016/j.fct.2018.04.017. Epub 2018 Apr 9.
The knowledge of aggregate exposure to different types of products is paramount in the risk assessment. The aim of this study was to compare the relative contribution of essential oils compared to cosmetics on the daily dermal exposure to limonene, an ubiquitous fragrance compound that can be an allergen depending on its degree of oxidation. Aggregate daily exposure to limonene was calculated among a panel of French volunteers using both essential oils and cosmetics, for 4 different specific zones, i.e. face and neck, chest, upper limbs and lower limbs. Calculations were made using a probabilistic Monte Carlo method and sensitivity analysis. The main strength of this work was the inclusion of essential oils in addition to cosmetics in the model. For the first time, the generated data could be used to compare the contribution of these two products in dermal exposure. Essential oils appear to be significant contributors to exposure to limonene particularly for the face. This work is a first step that will permit to determine the exposure to other fragrance compounds with sensitizing potential. These data will be useful for risk managers to consider the inclusion of essential oils in the overall burden of this pathology.
了解对不同类型产品的综合暴露情况对于风险评估至关重要。本研究的目的是比较与化妆品相比，香精油对柠檬烯（一种无处不在的香料化合物，其氧化程度决定其是否为过敏原）每日皮肤暴露的相对贡献。本研究通过对一组法国志愿者进行的研究，使用香精油和化妆品，计算了 4 个不同特定区域（面部和颈部、胸部、上肢和下肢）的柠檬烯的每日总暴露量。计算是使用概率蒙特卡罗方法和敏感性分析进行的。这项工作的主要优势在于在模型中除了化妆品外还纳入了香精油。这是首次生成的数据可用于比较这两种产品对皮肤暴露的贡献。香精油似乎是暴露于柠檬烯的重要因素，特别是对面部的影响。这项工作是第一步，将允许确定具有致敏潜力的其他香料化合物的暴露情况。这些数据对于风险管理者来说很有用，可考虑将香精油纳入这种疾病的总体负担。
