Lima Ellen Marise, Rzezak Patricia, Dos Santos Bernardo, Gentil Letícia, Montenegro Maria A, Guerreiro Marilisa M, Valente Kette D
Department of Psychiatry, Hospital das Clinicas, University of São Paulo-HCFMUSP, Sao Paulo, Brazil.
School of Nursing, University of São Paulo (USP), Sao Paulo, Brazil.
Epilepsy Behav. 2018 May;82:164-169. doi: 10.1016/j.yebeh.2018.03.017. Epub 2018 Apr 9.
In this study, we aimed to evaluate the attentional and executive functions in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS) with and without attention-deficit hyperactivity disorder (ADHD) compared with controls and compared with patients with ADHD without epilepsy. We evaluated 12 patients with BCECTS and ADHD (66.7% boys; mean age of 9.67years); 11 children with non-ADHD BCECTS (63.6% boys; mean age of 11.91years); 20 healthy children (75% boys; mean age of 10.15years); and 20 subjects with ADHD without epilepsy (60% boys; mean age of 10.9years). We used a comprehensive battery of neuropsychological tests to evaluate attentional and executive functions in their broad domains. Patients with BCECTS and ADHD had worse performance in Conners' Continuous Performance Test II (reaction time standard error [p=0.008], variability [p=0.033], perseverations [p=0.044] and in reaction time interstimuli interval [p=0.016]). Patients with ADHD showed worse performance in Trail Making Test B errors [p=0.012]. In conclusion, patients with BCECTS and ADHD had worse executive and attentional performance compared with controls than non-ADHD patients with BCECTS. Regardless of the presence of epilepsy, ADHD also negatively impacted executive and attentional functions but in different executive subdomains compared with patients with epilepsy.
在本研究中，我们旨在评估伴有和不伴有注意力缺陷多动障碍（ADHD）的儿童良性中央颞区棘波癫痫（BCECTS）患者的注意力和执行功能，并与对照组以及无癫痫的ADHD患者进行比较。我们评估了12例患有BCECTS和ADHD的患者（男孩占66.7%；平均年龄9.67岁）；11例患有非ADHD的BCECTS儿童（男孩占63.6%；平均年龄11.91岁）；20名健康儿童（男孩占75%；平均年龄10.15岁）；以及20名无癫痫的ADHD受试者（男孩占60%；平均年龄10.9岁）。我们使用了一系列全面的神经心理学测试来评估他们在广泛领域的注意力和执行功能。患有BCECTS和ADHD的患者在康纳斯连续操作测验II中的表现较差（反应时间标准误差[p = 0.008]、变异性[p = 0.033]、持续性错误[p = 0.044]以及反应时间刺激间隔[p = 0.016]）。患有ADHD的患者在连线测验B错误方面表现更差[p = 0.012]。总之，与对照组相比，患有BCECTS和ADHD的患者的执行和注意力表现比不患有ADHD的BCECTS患者更差。无论是否存在癫痫，ADHD也会对执行和注意力功能产生负面影响，但与癫痫患者相比，其在不同的执行子领域。
