Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan.
Blood Purif. 2018;46(1):12-18. doi: 10.1159/000486233. Epub 2018 Apr 12.
BACKGROUND/AIMS: We investigated factors associated with functional performance in hemodialysis (HD) patients as well as their relationships with mortality.
We enrolled 790 HD patients who were followed up from 2009 to 2013. Functional performance was evaluated by Karnofsky Performance Status Scale (KPSS) scores. We examined the associations of clinical variables and all-cause mortality with KPSS scores.
Of the participants, 460 had high KPSS scores (range 90-100) and 330 had low KPSS scores (below 80). On multivariate analysis, age and weekly HD sessions were associated with significantly increased odds of a lower KPSS score (age: OR 1.05, 95% CI 1.04-1.07, p < 0.001; weekly HD: OR 2.10, 95% CI 1.37-3.21, p = 0.001). A low KPSS score was a significant predictor of increased all-cause mortality (hazard ratio 1.49; 95% CI 1.02-2.16, p = 0.037), as determined using Cox regression analysis.
Functional performance was associated with clinical variables and all-cause mortality in HD patients.
背景/目的：我们研究了与血液透析（HD）患者功能表现相关的因素及其与死亡率的关系。
我们纳入了 790 名接受 HD 治疗并于 2009 年至 2013 年进行随访的患者。功能表现通过 Karnofsky 表现状态量表（KPSS）评分进行评估。我们检验了临床变量与全因死亡率与 KPSS 评分之间的相关性。
参与者中，460 人 KPSS 评分较高（90-100 分），330 人 KPSS 评分较低（低于 80 分）。多变量分析显示，年龄和每周 HD 治疗次数与 KPSS 评分较低显著相关（年龄：OR 1.05，95%CI 1.04-1.07，p<0.001；每周 HD：OR 2.10，95%CI 1.37-3.21，p=0.001）。KPSS 评分较低是全因死亡率增加的显著预测因素（风险比 1.49；95%CI 1.02-2.16，p=0.037），这是通过 Cox 回归分析确定的。
功能表现与 HD 患者的临床变量和全因死亡率相关。
