Zampetti Simona, Campagna Giuseppe, Leto Gaetano, Lucantoni Federica, D'Onofrio Luca, Marandola Lidia, Moretti Chiara, Chiesa Claudio, Pacifico Lucia, Buzzetti Raffaella
Department of Experimental Medicine, Sapienza University, Rome, Italy.
Institute of Translational Pharmacology, National Research Council, Rome, Italy.
Am J Cardiol. 2018 Jun 15;121(12):1624-1628. doi: 10.1016/j.amjcard.2018.02.057. Epub 2018 Mar 14.
The aim of this study was to assess the relation of wrist circumference with changes in left ventricular (LV) structure in a population of overweight/obese children and adolescents. One hundred and six children and adolescents were consecutively enrolled. In all subjects body weight, height, wrist circumference, waist circumference, body mass index-standard deviation score, fasting glucose, insulin, lipid profile, and blood pressure were evaluated. All subjects underwent echocardiographic assessment, and the following parameters were evaluated: LV dimension at end diastole and LV dimension at end systole, LV posterior wall thickness at end diastole and LV posterior wall thickness at end systole, interventricular septal thickness at end diastole and interventricular septal thickness at end systole, LV mass, and epicardial adipose tissue (EAT). LV hypertrophy was defined as LVM Index ≥95th percentile. Wrist circumference correlated with all parameters of LV dimensions and LV mass (p <0.0001) and EAT (p = 0.04). The strongest correlations were reported between wrist circumference with LV dimension at end diastole and LV dimension at end systole (r = 0.73 and r = 0.68 respectively, p <0.0001, for both). Results of the multivariate regression analysis showed that wrist circumference was significantly associated with all parameters of LV dimensions, LV mass, and EAT (p ≤0.002). The logistic regression showed that wrist circumference was significantly associated with LV hypertrophy (odds ratio 1.39, p = 0.046). In conclusion, wrist circumference could be a useful measure of cardiovascular risk in obese children and adolescents, opening new perspectives in the prediction of cardiovascular diseases.
本研究的目的是评估超重/肥胖儿童及青少年群体中腕围与左心室（LV）结构变化之间的关系。连续招募了106名儿童及青少年。对所有受试者评估了体重、身高、腕围、腰围、体重指数标准差评分、空腹血糖、胰岛素、血脂谱和血压。所有受试者均接受了超声心动图评估，并评估了以下参数：舒张末期左心室内径、收缩末期左心室内径、舒张末期左心室后壁厚度、收缩末期左心室后壁厚度、室间隔舒张末期厚度、室间隔收缩末期厚度、左心室质量和心外膜脂肪组织（EAT）。左心室肥厚定义为左心室质量指数≥第95百分位数。腕围与左心室尺寸和左心室质量的所有参数（p<0.0001）以及EAT（p = 0.04）相关。腕围与舒张末期左心室内径和收缩末期左心室内径之间的相关性最强（r分别为0.73和0.68，两者p<0.0001）。多变量回归分析结果显示，腕围与左心室尺寸、左心室质量和EAT的所有参数均显著相关（p≤0.002）。逻辑回归显示，腕围与左心室肥厚显著相关（优势比1.39，p = 0.046）。总之，腕围可能是肥胖儿童及青少年心血管风险的一个有用指标，为心血管疾病的预测开辟了新的前景。
