Abassi Wissal, Ouerghi Nejmeddine, Hammami Mohamed Bessem, Jebabli Nidhal, Feki Moncef, Bouassida Anissa, Weiss Katja, Knechtle Beat
Research Unit "Sport Sciences, Health and Movement" (UR22JS01), High Institute of Sport and Physical Education of Kef, University of Jendouba, Kef 7100, Tunisia.
Faculty of Medicine of Tunis, Rabta Hospital, LR99ES11, University of Tunis El Manar, Tunis 1007, Tunisia.
Nutrients. 2025 Jan 1;17(1):164. doi: 10.3390/nu17010164.
BACKGROUND/OBJECTIVES: Despite the abundant body of evidence linking high-intensity interval training (HIIT) to cardiometabolic markers, little is known about how HIIT affects liver enzymes, particularly in obese adolescents. This study aimed to investigate the effects of HIIT on metabolic dysfunction-associated steatotic liver disease (MASLD)-related biomarkers in overweight/obese adolescent girls.
Thirty-three overweight/obese adolescent girls (age, 17.0 ± 1.15 yr.; body mass index, 33.3 ± 4.77 kg/m) were randomly assigned to HIIT ( = 17) or control ( = 16) groups. The HIIT group participated in a nine-week HIIT program (three times weekly) without caloric restriction. Maximal aerobic speed, body composition indexes, blood pressure, MASLD-related biomarkers [liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), plasma lipids, uric acid, platelet count, and homeostasis model assessment index for insulin-resistance (HOMA-IR)] were examined at baseline and after the intervention.
Significant "time × group" interactions were found for body composition indexes, systolic blood pressure, maximal aerobic speed, liver enzymes ALT and AST, plasma lipids, glucose, and HOMA-IR. The HIIT program resulted in an increase in maximal aerobic speed ( = 0.035) and a decrease in body composition and plasma lipids ( < 0.01), systolic blood pressure ( = 0.011), ALT ( = 0.013), AST ( = 0.012), and HOMA-IR ( = 0.01), but no significant changes in uric acid and platelet count. None of these markers changed in the control group.
HIIT resulted in an improvement in MASLD-related biomarkers. HIIT could be an effective exercise therapy to prevent and reverse MASLD in adolescents with obesity.
背景/目的：尽管有大量证据表明高强度间歇训练（HIIT）与心脏代谢指标有关，但对于HIIT如何影响肝酶，尤其是在肥胖青少年中，人们了解甚少。本研究旨在调查HIIT对超重/肥胖青春期女孩代谢功能障碍相关脂肪性肝病（MASLD）相关生物标志物的影响。
33名超重/肥胖青春期女孩（年龄17.0±1.15岁；体重指数33.3±4.77kg/m）被随机分为HIIT组（n = 17）或对照组（n = 16）。HIIT组参加为期九周的HIIT计划（每周三次），不限制热量摄入。在基线和干预后检测最大有氧速度、身体成分指标、血压、MASLD相关生物标志物[肝酶（丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST））、血脂、尿酸、血小板计数和胰岛素抵抗稳态模型评估指数（HOMA-IR）]。
在身体成分指标、收缩压、最大有氧速度、肝酶ALT和AST、血脂、血糖和HOMA-IR方面发现了显著的“时间×组”交互作用。HIIT计划导致最大有氧速度增加（P = 0.035），身体成分和血脂降低（P < 0.01），收缩压（P = 0.011）、ALT（P = 0.013）、AST（P = 0.012）和HOMA-IR（P = 0.01）降低，但尿酸和血小板计数无显著变化。对照组这些指标均无变化。
HIIT可改善MASLD相关生物标志物。HIIT可能是预防和逆转肥胖青少年MASLD的有效运动疗法。
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