Reverso-Meinietti J, Vandenbos F, Risso K, Coyne J, Leroy S, Padovani B, Burel-Vandenbos F
Laboratoire central d'anatomie pathologique, hôpital Pasteur, centre hospitalier universitaire de Nice, 30, voie Romaine, 06000 Nice, France.
Centre de soins de suite et de rééducation cardiorespiratoire « La Maison du Mineur », 755, avenue Henri-Giraud, 06140 Vence, France.
Rev Med Interne. 2018 Aug;39(8):658-660. doi: 10.1016/j.revmed.2018.03.017. Epub 2018 Apr 9.
Pulmonary intravascular talcosis is a rare condition occurring in intravenous drug users injecting oral medications. Talc results in a foreign-body granulomatous reaction giving a radiological haematogenic miliary appearance mimicking miliary tuberculosis. Drug users represent a population at risk for both these conditions and their distinction may be challenging.
We reported the case of a man, 33 year-old, intravenous drug addict, detected by the health services because he was the partner of a person who died of contagious and multi-resistant tuberculosis. Chest X-ray and CT scan showed a typical miliary appearance. Despite negative microbiology, clinical diagnosis of miliary tuberculosis was retained. Due to the lack of radiological improvement despite appropriate antibiotic treatment, re-evaluation and trans-bronchial biopsy were undertaken. The presence of granulomas centered by birefringent foreign bodies in polarized light led to a diagnosis of pulmonary intravascular talcosis.
In the presence of pulmonary miliary in an intravenous drug addict, intravascular talcosis should be suspected.
肺血管滑石粉沉着症是一种发生在注射口服药物的静脉吸毒者中的罕见病症。滑石粉会引发异物肉芽肿反应,在影像学上呈现血行播散性粟粒样表现,酷似粟粒型肺结核。吸毒者是这两种病症的高危人群,区分它们可能具有挑战性。
我们报告了一名33岁男性静脉吸毒者的病例,他因是一名死于传染性多重耐药结核病患者的伴侣而被卫生服务机构发现。胸部X线和CT扫描显示出典型的粟粒样表现。尽管微生物学检查结果为阴性,但仍保留粟粒型肺结核的临床诊断。由于在适当的抗生素治疗后影像学上没有改善,因此进行了重新评估和经支气管活检。在偏振光下以双折射异物为中心存在肉芽肿,从而诊断为肺血管滑石粉沉着症。
静脉吸毒者出现肺部粟粒样病变时,应怀疑血管内滑石粉沉着症。