Department of Endocrinology, Ioannina University Hospital, Ioannina, Greece.
Department of Internal Medicine, Ioannina University Hospital, Ioannina, Greece.
J Clin Lipidol. 2018 May-Jun;12(3):826-829. doi: 10.1016/j.jacl.2018.03.078. Epub 2018 Mar 13.
We report the case of a patient with probable heterozygous familial hypercholesterolemia and mitotane-induced resistant hypercholesterolemia, despite combination therapy with rosuvastatin and ezetimibe. The patient was managed with the addition of evolocumab. Use of a proprotein convertase subtilisin-kexin type 9 inhibitor, should be considered in patients who develop mitotane-related hypercholesterolemia that cannot be managed with conventional lipid-lowering treatment.
我们报告了一例可能为杂合子家族性高胆固醇血症和米托坦诱导的耐药性高胆固醇血症的患者，尽管联合使用瑞舒伐他汀和依折麦布进行治疗。该患者加用依洛尤单抗进行治疗。对于发生米托坦相关的高胆固醇血症且不能通过常规降脂治疗控制的患者，应考虑使用前蛋白转化酶枯草溶菌素 9 抑制剂。
