遗传学能否阐明 Notch 在造血干细胞中的作用？
Can genetics resolve what Notch does in HSCs?
机构信息
University of Pennsylvania.
出版信息
Blood. 2018 Apr 12;131(15):1633-1635. doi: 10.1182/blood-2018-02-829069.
Abstract
The effects of Notch signaling in hematopoietic stem and progenitor cells remain controversial. In work presented in this issue of , Duarte et al interfere genetically with the Notch transcriptional complex (NTC) in hematopoiesis and demonstrate that canonical Notch signals are dispensable in primitive hematopoietic progenitors, as well as across the myeloid, erythroid (E), and megakaryocyte (Mk) lineages.
摘要
Notch 信号在造血干/祖细胞中的作用仍存在争议。在本期 杂志中，Duarte 等人通过遗传干扰造血中的 Notch 转录复合物（NTC），证明了经典 Notch 信号在原始造血祖细胞以及髓系、红系（E）和巨核细胞（Mk）谱系中是可有可无的。
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