Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, 210006, Nanjing, China.
Department of Cardiology, Nanjing Central Hospital, Jiangsu, 210018, Nanjing, China.
Exp Mol Med. 2018 Apr 13;50(4):1-7. doi: 10.1038/s12276-018-0043-z.
Life-threatening malignant arrhythmias in pathophysiological conditions can increase the mortality and morbidity of patients with cardiovascular diseases. Cardiac electrical activity depends on the coordinated propagation of excitatory stimuli and the generation of action potentials in cardiomyocytes. Action potential formation results from the opening and closing of ion channels. Recent studies have indicated that small-conductance calcium-activated potassium (SK) channels play a critical role in cardiac repolarization in pathophysiological but not normal physiological conditions. The aim of this review is to describe the role of SK channels in healthy and diseased hearts, to suggest cardiovascular pathophysiologic targets for intervention, and to discuss studies of agents that target SK channels for the treatment of cardiovascular diseases.
危及生命的恶性心律失常可增加心血管疾病患者的死亡率和发病率。心脏电活动依赖于兴奋刺激的协调传播和心肌细胞动作电位的产生。动作电位的形成是由离子通道的开启和关闭引起的。最近的研究表明，小电导钙激活钾（SK）通道在病理生理而非正常生理条件下对心脏复极起关键作用。本综述旨在描述 SK 通道在健康和患病心脏中的作用，提出心血管病理生理干预靶点，并讨论针对 SK 通道的药物治疗心血管疾病的研究。
