Metwally Fateheya M, Rashad Hend, Zeidan Hala M, Kilany Ayman, Abdol Raouf Ehab R
1Environmental Research Division, Occupational and Environmental Medicine Department, National Research Centre, Cairo, Egypt.
2Medical Research Division, Research on Children with Special Needs Department, National Research Centre, Cairo, Egypt.
Indian J Clin Biochem. 2018 Apr;33(2):196-201. doi: 10.1007/s12291-017-0667-0. Epub 2017 Jun 5.
The role of bisphenol A (BPA) in autism was investigated in 49 children (mean age = 5.950 ± 1.911 years) with autism spectrum disorders (ASDs) and 40 comparable age and sex matched children used as controls (mean age = 5.333 ± 2.279 years). In addition, 8-Hydroxydeoxyguanosine (8-oxodG) was also studied as a biomarker of oxidative stress in the same set of two selected groups. The results showed that both BPA and 8-oxodG were significantly higher in children with autism than those of control children ( values = 0.025 and 0.0001, respectively). There were positive correlations between both BPA and 8-oxodG with ASDs severity ( = 0.400 and 0.805, respectively), these correlations were highly significant ( values = 0.004 and 0.001, respectively). There was a significance positive correlation between BMI and BPA, but the correlation between BMI and 8-oxodG was not significant in children with autism. The observed results revealed that BPA may increase oxidative stress resulting in mitochondrial dysfunction that affecting the behavior and functioning of ASDs children.
研究了双酚A（BPA）在自闭症中的作用，研究对象为49名患有自闭症谱系障碍（ASD）的儿童（平均年龄=5.950±1.911岁）以及40名年龄和性别匹配的儿童作为对照（平均年龄=5.333±2.279岁）。此外，还在这两组选定的儿童中研究了8-羟基脱氧鸟苷（8-oxodG）作为氧化应激的生物标志物。结果显示，自闭症儿童体内的双酚A和8-oxodG均显著高于对照儿童（P值分别为0.025和0.0001）。双酚A和8-oxodG与自闭症严重程度均呈正相关（r值分别为0.400和0.805），这些相关性均高度显著（P值分别为0.004和0.001）。在自闭症儿童中，体重指数（BMI）与双酚A之间存在显著正相关，但BMI与8-oxodG之间的相关性不显著。观察结果表明，双酚A可能会增加氧化应激，导致线粒体功能障碍，进而影响自闭症儿童的行为和功能。
