Metwally Fateheya M, Rashad Hend, Zeidan Hala M, Hashish Adel F
1Environmental Research Division, Occupational and Environmental Medicine Department, National Research Centre, Cairo, Egypt.
2Medical Research Division, Research on Children with Special Needs Department, National Research Centre, Cairo, Egypt.
Indian J Clin Biochem. 2020 Apr;35(2):205-210. doi: 10.1007/s12291-018-0801-7. Epub 2018 Dec 10.
Early developmental exposures to endocrine disruptors including bisphenol A (BPA) may affects the body's endocrine system producing adverse neurologic, reproductive, cardiovascular, metabolic, and immune effects in humans. Many studies show the effect of BPA on human reproduction at lower concentrations than that of the safety limit recommendations. However, limited studies have been associated between environmental exposure of BPA and gonadotropic hormone levels in children with autism spectrum disorders (ASDs). This study was done to evaluate association between the serum levels of hormones; follicle-stimulating (FSH), inhibin B (INHB), and estradiol (E2) and BPA in 49 ASD children compared with 40 healthy control children. Serum levels of FSH, INHB, and E2 were lower in ASD group than that of control. Correlations between BPA and FSH, INHB, and E2 within autistic children were not significant. The observed results revealed that BPA may cause endocrine dysfunction in ASD children.
早期接触包括双酚A（BPA）在内的内分泌干扰物可能会影响人体内分泌系统，对人类产生不良的神经、生殖、心血管、代谢和免疫影响。许多研究表明，BPA在低于安全限值建议的浓度下对人类生殖有影响。然而，关于环境中BPA暴露与自闭症谱系障碍（ASD）儿童促性腺激素水平之间的关联研究较少。本研究旨在评估49名ASD儿童与40名健康对照儿童的血清激素水平（促卵泡生成素（FSH）、抑制素B（INHB）和雌二醇（E2））与BPA之间的关联。ASD组的FSH、INHB和E2血清水平低于对照组。自闭症儿童体内BPA与FSH、INHB和E2之间的相关性不显著。观察结果表明，BPA可能导致ASD儿童内分泌功能障碍。
