Barton James C, Edmunds Hayward S
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Southern Iron Disorders Center, Birmingham, AL, USA.
Case Rep Hematol. 2018 Jan 30;2018:5616898. doi: 10.1155/2018/5616898. eCollection 2018.
infections have been described in patients with diverse types of malignancy, especially leukemia. We report the case of a 65-year-old man with previously untreated hairy cell leukemia characterized by CD5 positivity and trisomy 12 (3% of blood lymphocytes) who developed bacteremia due to serotype 1/2b. We summarize clinical features and treatment of this patient and five previously reported patients with hairy cell leukemia who also had infections. All six patients were men. Their mean age at infection diagnosis was 70 y. Three men had undergone splenectomy 4-11 y before they developed infection. The central nervous system was the primary site of infection in four men. Bacteremia alone occurred in two other men. At diagnosis of infection, one man was receiving antileukemia chemotherapy and another man was receiving treatment for Kaposi's sarcoma. Two other patients had other comorbid conditions. All six men recovered from their infections.
不同类型恶性肿瘤患者，尤其是白血病患者中曾有感染的相关报道。我们报告了一例65岁男性患者，其患有先前未经治疗的毛细胞白血病，特征为CD5阳性和12号染色体三体（血液淋巴细胞的3%），该患者因1/2b血清型发生了菌血症。我们总结了该患者以及另外五例先前报道的同样患有感染的毛细胞白血病患者的临床特征和治疗情况。所有六名患者均为男性。他们感染诊断时的平均年龄为70岁。三名男性在发生感染前4 - 11年接受了脾切除术。四名男性的中枢神经系统是感染的主要部位。另外两名男性仅发生了菌血症。在感染诊断时，一名男性正在接受抗白血病化疗，另一名男性正在接受卡波西肉瘤的治疗。另外两名患者有其他合并症。所有六名男性的感染均已康复。
