Gascón Nieves, Pérez-Montero Héctor, Guardado Sandra, D'Ambrosi Rafael, Cabeza María Ángeles, Pérez-Regadera José Fermín
Radiation Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Case Rep Hematol. 2018 Feb 13;2018:6730567. doi: 10.1155/2018/6730567. eCollection 2018.
Here, we describe the case of a 66-year-old male diagnosed with multiple myeloma who presented with generalized tonic-clonic seizures. Magnetic resonance imaging demonstrated a right solid extra-axial parieto-occipital lesion with typical characteristics of meningeal myelomatosis. Biopsy was performed, which diagnosed a dural plasmacytoma. Because of this, we started concomitant therapy with radiotherapy and lenalidomide, but the patient has a poor response to treatment and died few weeks after its initiation. Myelomatous involvement of the dura mater is a rare occurrence, given that only few cases were reported in the English literature. This presentation confers an ominous prognosis and must be a suspect diagnosis in patients diagnosed with multiple myeloma presenting neurological symptoms.
在此，我们描述一例66岁男性，诊断为多发性骨髓瘤，出现全身强直阵挛性癫痫发作。磁共振成像显示右侧实性轴外顶枕部病变，具有脑膜骨髓瘤病的典型特征。进行了活检，诊断为硬脊膜浆细胞瘤。因此，我们开始同时进行放疗和来那度胺治疗，但患者对治疗反应不佳，治疗开始几周后死亡。硬脊膜的骨髓瘤累及很少见，因为英文文献中仅报道了少数病例。这种表现预示预后不良，对于诊断为多发性骨髓瘤且出现神经症状的患者必须怀疑有此诊断。
