Halczuk I, Iłzecka J, Stelmasiak Z
Katedry i Kliniki Neurologii, Akademii Medycznej w Lublinie.
Neurol Neurochir Pol. 1999 Nov-Dec;33(6):1425-33.
Multiple myeloma is characterized by the production of a monoclonal immunoglobulin. Myelomatous meningitis is a rare occurrence in multiple myeloma. The signs of meningeal myelomatosis include impairment of consciousness, cranial nerve palsies, convulsions and plasmatic cells in the cerebrospinal fluid. Atypical, plasmatic cells in the cerebrospinal fluid are an important finding for the diagnosis of meningeal myeloma. A combination of radiation therapy and chemotherapy is the usual treatment. Patients with meningeal myelomatosis can have a good response to treatment initially, but their prognosis is poor and death occurs within a few months. We present the case of a woman with myelomatous meningitis. Multiple myeloma was diagnosed by serum protein electrophoresis and bone marrow aspiration. This case and a review of the literature show that clinical manifestations of meningeal myeloma are non-specific.
多发性骨髓瘤的特征是产生单克隆免疫球蛋白。骨髓瘤性脑膜炎在多发性骨髓瘤中较为罕见。脑膜骨髓瘤病的体征包括意识障碍、脑神经麻痹、抽搐以及脑脊液中的浆细胞。脑脊液中出现非典型浆细胞是诊断脑膜骨髓瘤的一项重要发现。放疗和化疗联合是常用的治疗方法。脑膜骨髓瘤病患者最初对治疗可能有良好反应，但预后较差，会在数月内死亡。我们报告一例患有骨髓瘤性脑膜炎的女性病例。通过血清蛋白电泳和骨髓穿刺诊断为多发性骨髓瘤。该病例及文献回顾表明，脑膜骨髓瘤的临床表现不具有特异性。
