Department of Chemical Engineering , Texas A&M University , College Station , Texas 77843 , United States.
ACS Sens. 2018 Apr 27;3(4):852-857. doi: 10.1021/acssensors.8b00098. Epub 2018 Apr 18.
Surface-enhanced Raman scattering (SERS) is a powerful analytical tool which enables the detection and identification of analytes adsorbed on nanostructured noble metals. However, SERS analysis of complex mixtures can be challenging due to spectral overlap and interference. In this report, we demonstrate a method to simplify the identification of mixed-analyte samples by coupling SERS detection with chromatographic separation on a nanoplasmonic paper substrate. This "nanopaper" substrate is a silver coated glass microfiber filter paper which possesses large SERS enhancement and can serve as a stationary phase in paper chromatography. Nanopaper is easily synthesized using the silver mirror reaction, making it a highly accessible technology. Nanopaper was successfully used as a combined paper chromatography-SERS (PC-SERS) substrate in the separation and identification of mixed organic dyes. It was further employed to separate and identify lycopene and β-carotene in commercial food products, demonstrating the versatility and utility of nanopaper in the identification of complex mixtures.
表面增强拉曼散射（SERS）是一种强大的分析工具，可用于检测和识别吸附在纳米结构贵金属上的分析物。然而，由于光谱重叠和干扰，复杂混合物的 SERS 分析具有一定的挑战性。在本报告中，我们展示了一种通过将 SERS 检测与纳米等离子体纸基上的色谱分离相结合，简化混合分析物样品鉴定的方法。这种“纳米纸”基片是一种涂银的玻璃微纤维滤纸，具有较大的 SERS 增强效果，可以作为纸色谱中的固定相。纳米纸可以通过银镜反应很容易地合成，因此是一种高度可及的技术。纳米纸成功地用作混合有机染料分离和鉴定的纸色谱-表面增强拉曼散射（PC-SERS）基片。它进一步用于分离和鉴定商业食品中的番茄红素和β-胡萝卜素，展示了纳米纸在复杂混合物鉴定中的多功能性和实用性。
