Chepelyuk A A, Vinogradova M G, Kovalenok T V, Dorofeeva O A, Metlina M V, Neznamov G G
Zakusov Institute of Pharmacology, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.
Lomonosov Moscow State University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3):4-9. doi: 10.17116/jnevro2018118314-9.
To study the relationship between cognitive functions and psychopathological disturbances in anxiety disorders.
WAIS, the modified Witkin's Embedded figures test, a symptom scale (Yu.A. Aleksandrovsky et al. 1984) were administered to 111 patients, including 37 with generalized anxiety disorders (GAD, ICD-10 F41.1), 36 with anxiety-phobic disorders (AFD, ICD-10 F40) and 38 with anxiety-hypochondriac disorders (AHD, ICD-10 F45.2), and to 114 healthy people.
A distinct trend towards an increase of cognitive impairment depending on an increase in the complicity of psychopathological picture was observed as follows: GAD - AFD - AHD. A decrease in visual-motor coordination and visual attention was found in patients with GAD. In AFD patients, besides disturbances characteristic of GAD, there was a decrease on the WAIS Vocabulary subtest. In AHD patients, there was a decrease in analytic and synthetic abilities. The heterogeneity of changes in cognitive processes and the structure of their correlations with psychopathological symptoms in anxiety disorders was revealed as follows: a decrease in some parameters of cognitive processes in anxiety disorders with mild structure, an increase in cognitive dysfunction and in a number of correlations in anxiety disorders with more complex psychopathological picture, higher scores on the WAIS Block design task.
研究焦虑症患者认知功能与精神病理障碍之间的关系。
对111例患者及114名健康人进行了韦氏成人智力量表（WAIS）、改良的威特金镶嵌图形测验以及一种症状量表（Yu.A. 亚历山德罗夫斯基等人，1984年）测试。111例患者中包括37例广泛性焦虑症（GAD，国际疾病分类第十版F41.1）患者、36例焦虑恐惧症（AFD，国际疾病分类第十版F40）患者和38例焦虑疑病症（AHD，国际疾病分类第十版F45.2）患者。
观察到随着精神病理状况复杂性增加，认知障碍有明显加重趋势，具体如下：GAD - AFD - AHD。GAD患者视觉运动协调能力和视觉注意力下降。AFD患者除具有GAD的特征性障碍外，韦氏成人智力量表词汇分测验得分也下降。AHD患者分析和综合能力下降。焦虑症患者认知过程变化的异质性及其与精神病理症状的相关性结构如下：结构较轻的焦虑症患者某些认知过程参数下降，精神病理状况较复杂的焦虑症患者认知功能障碍及一些相关性增加，韦氏成人智力量表积木图案测验得分较高。
