Neznamov G G, Bochkarev V K
Zakusov Institute of Pharmacology, Moscow, Russia.
Serbsky Federal Medical Research Centre for Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(9):53-60. doi: 10.17116/jnevro201811809153.
To study the relationship between subjective evaluation (SE) of the effect of single test doses of benzodiazepine anxiolytic phenazepam and placebo and objective electroencephalography (EEG) characteristics in patients with anxiety disorders.
Forty patients, including 13 with generalized anxiety disorders (GAD, ICD-10 F41.1), 13 with anxiety-phobic disorders (AFD, ICD-10 F40.0) and 14 with anxiety-hypochondriac disorders (AHD, ICD-10 F45.2), were enrolled. The method of subjective evaluation of the effect of psychotropic drugs and EEG recording during wakeful rest and 2 hours after taking test doses of phenazepam (1 mg) and placebo were performed.
A trend towards the higher SE indices (tolerability and a wish to continue treatment with the drug) of the test dose of phenazepam in patients with GAD, its decrease in AFD and AHD, no differences in SE indices of placebo between different psychopathological patterns of disorders were identified. The changes in EEG specific for benzodiazepines were revealed in patients treated with phenazepam. Insignificant changes in the beta rhythm after taking placebo were found. Correlations between subjective assessments of the effect of test doses of phenazepam and placebo and EEG were observed. The results suggest that subjective assessments of the effect of anxiolytic drugs and objective indices of anxiolytic drug action are interrelated.
研究单次试验剂量的苯二氮䓬类抗焦虑药非那西泮与安慰剂对焦虑症患者的主观评价（SE）与客观脑电图（EEG）特征之间的关系。
纳入40例患者，其中13例广泛性焦虑障碍（GAD，国际疾病分类第十版F41.1）患者、13例焦虑恐惧症（AFD，国际疾病分类第十版F40.0）患者和14例焦虑疑病症（AHD，国际疾病分类第十版F45.2）患者。采用精神药物疗效主观评价方法，并在清醒休息时以及服用试验剂量非那西泮（1毫克）和安慰剂2小时后进行脑电图记录。
GAD患者中，非那西泮试验剂量的SE指数（耐受性和继续用药意愿）有升高趋势，AFD和AHD患者中该指数下降，不同精神病理模式的疾病之间安慰剂的SE指数无差异。服用非那西泮的患者出现了苯二氮䓬类药物特有的脑电图变化。服用安慰剂后β节律有不显著变化。观察到非那西泮和安慰剂试验剂量疗效的主观评估与脑电图之间存在相关性。结果表明，抗焦虑药物疗效的主观评估与抗焦虑药物作用的客观指标相互关联。
