School of Environmental Engineering, University of Seoul, Seoulsiripdaero 163, Dongdaemun-gu, Seoul 02504, Korea.
Consumer Product & Environment Business Division, KOTITI Testing & Research Institute, 111 Sagimakgol-ro, Jungwon-gu, Seongnam-si, Gyeonggi-do 13202, Korea.
Int J Environ Res Public Health. 2018 Apr 13;15(4):744. doi: 10.3390/ijerph15040744.
The inhalation of a water aerosol from a humidifier containing disinfectants has led to serious lung injuries in Korea. To promote the safe use of products, the Korean government enacted regulations on the chemicals in various consumer products that could have adverse health effects. Given the concern over the potential health risks associated with the hazardous ingredients in deodorizing consumer products, 17 ingredients were analyzed and assessed according to their health risk on 3 groups by the application type in 47 deodorizing products. The risk assessment study followed a stepwise procedure (e.g., collecting toxicological information, hazard identification/exposure assessment, and screening and detailed assessment for inhalation and dermal routes). The worst-case scenario and maximum concentration determined by the product purpose and application type were used as the screening assessment. In a detailed assessment, the 75th exposure factor values were used to estimate the assumed reasonable exposure to ingredients. The exposed concentrations of seven ingredients were calculated. Due to limitation of toxicity information, butylated hydroxyl toluene for a consumer’s exposure via the dermal route only was conducted for a detailed assessment. This study showed that the assessed ingredients have no health risks at their maximum concentrations in deodorizing products. This approach can be used to establish guidelines for ingredients that may pose inhalation and dermal hazards.
加湿器水气溶胶吸入含消毒剂已导致严重的肺部损伤在韩国。为了促进产品的安全使用,韩国政府颁布了有关法规的化学品在各种消费产品,可能对健康有不良影响。鉴于对与除臭消费产品的危险成分相关的潜在健康风险的关注,分析了 17 种成分,并根据其健康风险,按应用类型对 47 种除臭产品进行了分组评估。风险评估研究遵循逐步程序(例如,收集毒理学信息、危害识别/暴露评估,以及对吸入和皮肤途径进行筛选和详细评估)。最坏情况场景和由产品用途和应用类型确定的最大浓度用作筛选评估。在详细评估中,使用 75 个暴露因素值来估计成分的假定合理暴露量。计算了七种成分的暴露浓度。由于毒性信息的限制,仅对消费者通过皮肤途径接触的丁基羟基甲苯进行了详细评估。本研究表明,在所评估的除臭产品的最大浓度下,这些成分没有健康风险。这种方法可用于为可能存在吸入和皮肤危害的成分制定指导方针。