RSRC1 和 CPZ 基因多态性与中国儿童神经母细胞瘤易感性的关系。
RSRC1 and CPZ gene polymorphisms with neuroblastoma susceptibility in Chinese children.
机构信息
Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
Department of Clinical Laboratory, Molecular Epidemiology Laboratory, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China.
出版信息
Gene. 2018 Jul 1;662:83-87. doi: 10.1016/j.gene.2018.04.015. Epub 2018 Apr 10.
Two new neuroblastoma susceptibility loci at 3q25 (RSRC1 rs6441201 G > A) and 4p16 (CPZ rs3796725 T > C and rs3796727 A > G) were identified by a genome-wide association study (GWAS) involving Italians, African Americans and European Americans. In this case-control study with 393 neuroblastoma cases and 812 controls, we investigated the association between these three polymorphisms and neuroblastoma susceptibility in Chinese population. We found that participants harboring the RSRC1 rs6441201A allele were associated with an increased risk of neuroblastoma (AA vs. GG: adjusted OR = 1.55, 95% CI = 1.03-2.34, P = 0.036). No significant association between the CPZ polymorphisms (rs3796725 T > C and rs3796727A > G) and neuroblastoma susceptibility was observed. In conclusion, our results confirm that the RSRC1 rs6441201A allele is associated with neuroblastoma susceptibility in Chinese population.
通过全基因组关联研究（GWAS），发现了两个新的神经母细胞瘤易感性基因座 3q25（RSRC1 rs6441201 G> A）和 4p16（CPZ rs3796725 T> C 和 rs3796727 A> G），该研究涉及意大利人、非裔美国人和欧洲裔美国人。在这项针对 393 例神经母细胞瘤病例和 812 例对照的病例对照研究中，我们研究了这三种多态性与中国人群神经母细胞瘤易感性之间的关系。我们发现，携带 RSRC1 rs6441201A 等位基因的参与者患神经母细胞瘤的风险增加（AA 与 GG：调整后的 OR=1.55，95%CI=1.03-2.34，P=0.036）。CPZ 多态性（rs3796725 T> C 和 rs3796727A> G）与神经母细胞瘤易感性之间没有显著关联。总之，我们的结果证实，RSRC1 rs6441201A 等位基因与中国人群的神经母细胞瘤易感性有关。
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