Inc-LAMC2-1:1 基因中的 rs2147578 C > G 多态性与河南儿童神经母细胞瘤风险增加相关。
The rs2147578 C > G polymorphism in the Inc-LAMC2-1:1 gene is associated with increased neuroblastoma risk in the Henan children.
机构信息
Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.
Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
出版信息
BMC Cancer. 2018 Oct 3;18(1):948. doi: 10.1186/s12885-018-4847-y.
BACKGROUND
The rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2-1:1 is associated with increased susceptibility to a few types of cancers. However, its role in neuroblastoma has not been evaluated yet.
METHODS
We investigated the association between the lnc-LAMC2-1:1 rs2147578 C > G polymorphism and neuroblastoma susceptibility in Chinese Han populations. A total of 393 neuroblastoma cases and 812 healthy individuals from the Henan and Guangdong provinces were enrolled and subjected to genotyping. Odds ratio (OR) and 95% confidence interval (CI) were used to determine the strength of the association of interest.
RESULTS
Combined analysis revealed that the lnc-LAMC2-1:1 rs2147578 C > G polymorphism was associated with increased neuroblastoma susceptibility (CG vs. CC: adjusted OR = 1.33, 95% CI = 1.01-1.75, P = 0.045; CG/GG vs. CC: adjusted OR = 1.34, 95% CI = 1.03-1.74, P = 0.028). In stratification analysis, children under 18 months with rs2147578 CG/GG genotypes had an increased neuroblastoma risk (adjusted OR = 1.70, 95% CI = 1.08-2.67, P = 0.022). Females with rs2147578 CG/GG genotypes also had increased neuroblastoma susceptibility (adjusted OR = 2.08, 95% CI = 1.37-3.18, P = 0.0007). In addition, children with lnc-LAMC2-1:1 rs2147578 CG/GG genotypes were prone to develop earlier stages of neuroblastoma (adjusted OR = 1.46, 95% CI = 1.01-2.12, P = 0.046).
CONCLUSIONS
The Lnc-LAMC2-1:1 rs2147578 C > G polymorphism may contribute to increased neuroblastoma susceptibility in children of Henan province.
背景
长链非编码 RNA 基因 Lnc-LAMC2-1:1 中的 rs2147578C>G 多态性与几种类型的癌症易感性增加有关。然而，其在神经母细胞瘤中的作用尚未得到评估。
方法
我们研究了汉族人群中长链非编码 RNA Lnc-LAMC2-1:1 rs2147578C>G 多态性与神经母细胞瘤易感性之间的关系。共纳入河南省和广东省的 393 例神经母细胞瘤病例和 812 例健康对照进行基因分型。比值比（OR）和 95%置信区间（CI）用于确定相关性的强度。
结果
合并分析显示，lnc-LAMC2-1:1 rs2147578C>G 多态性与神经母细胞瘤易感性增加相关（CG 与 CC：调整后的 OR=1.33，95%CI=1.01-1.75，P=0.045；CG/GG 与 CC：调整后的 OR=1.34，95%CI=1.03-1.74，P=0.028）。分层分析显示，18 个月以下 rs2147578CG/GG 基因型的儿童神经母细胞瘤风险增加（调整后的 OR=1.70，95%CI=1.08-2.67，P=0.022）。rs2147578CG/GG 基因型的女性神经母细胞瘤易感性也增加（调整后的 OR=2.08，95%CI=1.37-3.18，P=0.0007）。此外，lnc-LAMC2-1:1rs2147578CG/GG 基因型的儿童易发生神经母细胞瘤早期阶段（调整后的 OR=1.46，95%CI=1.01-2.12，P=0.046）。
结论
Lnc-LAMC2-1:1rs2147578C>G 多态性可能导致河南省儿童神经母细胞瘤易感性增加。
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