辅助生殖技术中孕激素过早升高的内分泌机制及检测问题。

Endocrine mechanisms and assay issues in premature progesterone elevation in assisted reproductive technology.

机构信息

Department of Obstetrics Gynecology and Reproductive Medicine, Hopital Foch-Faculté de Médecine Paris Ouest (UVSQ), Suresnes, France.

Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.

出版信息

Fertil Steril. 2018 Apr;109(4):571-576. doi: 10.1016/j.fertnstert.2018.02.137.

DOI:10.1016/j.fertnstert.2018.02.137

PMID:29653702

Abstract

Progesterone elevation occurring in the late phases of controlled ovarian stimulation (COS) has been reported for over 25 years. Yet doubts remain regarding the mechanisms at play in this phenomenon and its net consequences on assisted reproductive technology outcome, which is known to occur in poor and good assisted reproductive technology responders. The pathophysiology of end-COS progesterone elevation encountered in gonadotropin-suppressed cycles is different from that prevailing at the time of, and just after, ovulation. The different divergence in practical consequences of end-COS progesterone elevation led to review the progesterone assays developed for measuring progesterone in the luteal phase of the menstrual cycle, but commonly used for measuring all forms of progesterone elevation.

摘要

孕激素升高发生在控制性卵巢刺激（COS）的晚期已被报道超过 25 年。然而，对于这种现象的作用机制及其对辅助生殖技术结局的净影响仍存在疑问，已知在卵巢反应不良和良好的患者中均会发生。在促性腺激素抑制周期中遇到的 COS 晚期孕激素升高的病理生理学与排卵时和排卵后普遍存在的情况不同。COS 晚期孕激素升高的实际后果的不同差异促使人们回顾为测量月经周期黄体期孕激素而开发的孕激素检测方法，但这些方法通常也用于测量所有形式的孕激素升高。