Division of Reproductive Medicine, Department of Obstetrics and Gynecology and Reproductive Medicine, Foch Hospital, Suresnes, France.
Division of Reproductive Medicine, Department of Obstetrics and Gynecology and Reproductive Medicine, Foch Hospital, Suresnes, France.
Fertil Steril. 2018 Apr;109(4):563-570. doi: 10.1016/j.fertnstert.2018.02.132.
Over the past decades many of us have contributed to the controversy surrounding the origins and consequences of premature progesterone elevation during controlled ovarian stimulation. In this article, we attempt to retrace the progression of information on this complex subject which required reviewing a number of publications that often contradicted one another. The definition of premature progesterone elevation, the pathophysiological mechanisms underlying the high peripheral progesterone levels, and the debated consequences of this event on in vitro fertilixation-embryo transfer outcome will be addressed from a historical perspective.
在过去的几十年里，我们中的许多人都对控制性卵巢刺激中孕酮提前升高的起源和后果的争议做出了贡献。在本文中，我们试图追溯有关这一复杂主题的信息进展，为此需要查阅许多相互矛盾的出版物。我们将从历史的角度探讨孕酮提前升高的定义、外周高孕酮水平的病理生理机制，以及这一事件对体外受精-胚胎移植结果的有争议的后果。
