Faculty of Medical Sciences, Department of Pediatrics, University of Kragujevac, Kragujevac, Serbia.
Pediatric Clinic, Clinical Center Kragujevac, Kragujevac, Serbia.
Indian J Pediatr. 2018 Nov;85(11):968-973. doi: 10.1007/s12098-018-2676-2. Epub 2018 Apr 14.
To investigate the role of presepsin obtained from tracheal aspirate of intubated newborns in the diagnosis of early neonatal pneumonia.
A cross-sectional observational study was performed on 60 intubated newborns during the two-year period. Tracheal aspirate for examination was taken in aseptic conditions in usual toilets, by lavage with 2 ml of 0.9% NaCl in Mucus suction set. On the same day, presepsin (blood) was measured.
There were 34 newborns in the examined group (with pneumonia) and 26 in the control group. Patient groups were similar regarding demographic characteristics related to gender and Apgar score. The coefficients of simple linear correlation revealed the statistically significant connection between presepsin (from tracheal aspirate) and birth body weight, presepsin (plasma), maternal infection and pneumonia. Significant differences in the values of presepsin (from tracheal aspirate) (p < 0.001) and birth body weight (p = 0.036) were found.
In intubated newborns, measurements of presepsin obtained from tracheal aspirate suggested that it can be used as a complementary marker in diagnosing early onset neonatal pneumonia.
探讨经气管抽吸物中分离的前降钙素在诊断新生儿早发性肺炎中的作用。
对两年间 60 例气管插管新生儿进行横断面观察性研究。在常规条件下，通过黏液抽吸套件用 2 ml 0.9%生理盐水进行无菌冲洗，采集气管抽吸物进行检查。同日测定前降钙素（血）。
实验组（肺炎组）有 34 例新生儿，对照组有 26 例新生儿。两组在与性别和阿普加评分相关的人口统计学特征方面相似。简单线性相关系数显示，前降钙素（气管抽吸物）与出生体重、前降钙素（血浆）、母体感染和肺炎之间存在统计学显著关联。前降钙素（气管抽吸物）（p<0.001）和出生体重（p=0.036）的数值存在显著差异。
在气管插管的新生儿中，经气管抽吸物中分离的前降钙素的测量值提示其可作为诊断早发性新生儿肺炎的补充标志物。
