Orfanos C E, Hertel H
Universitäts-Hautklinik und Poliklinik, Freien Universität Berlin.
Z Hautkr. 1988 Jan 18;63(1):23-6.
Functional hyperprolactinemia was found in five female patients, 25-35 years old, seeking medical consultation for hair loss, together with hypertrichosis (4x), disturbances of cyclic bleeding periods (4x), secondary amenorrhea (2x), galactorrhea (2x), seborrhea (2x) and persisting acne (1x). Other hormonal parameters including testosterone levels and thyroid gland function tests were unchanged. Prolactinoma was excluded by x-ray diagrams, partly also by computer tomograms of the sella. In two patients increased telogen effluvium was found by trichogram examination with some dystrophic hairs; in one patient only dystrophic hairs were seen, whereas, in two cases, hair loss was not present at the time of our clinical examination. These observations indicate that cutaneous symptoms such as seborrhea, acne, hypertrichosis/hirsutism, alopecia(= SAHA syndrome) may evidently occur in hyperprolactinemia, representing or mimicking androgen-induced skin symptoms. In such cases, therefore, evaluation of prolactin levels together with androgen blood levels and thyroid gland function tests should be performed to exclude underlying endocrinopathy.
在5名年龄在25至35岁之间因脱发前来就医的女性患者中发现了功能性高催乳素血症，同时伴有多毛症（4例）、月经周期紊乱（4例）、继发性闭经（2例）、溢乳（2例）、脂溢性皮炎（2例）和持续性痤疮（1例）。包括睾酮水平和甲状腺功能测试在内的其他激素参数均未改变。通过X线片排除了催乳素瘤，部分病例也通过蝶鞍计算机断层扫描排除。通过毛发检查发现2例患者休止期脱发增加，伴有一些营养不良性毛发；1例患者仅见营养不良性毛发，而在2例患者中，我们临床检查时未发现脱发。这些观察结果表明，高催乳素血症中可能明显出现皮肤症状，如脂溢性皮炎、痤疮、多毛症/多毛、脱发（即SAHA综合征），表现或模仿雄激素诱导的皮肤症状。因此，在这种情况下，应同时评估催乳素水平、雄激素血水平和甲状腺功能测试，以排除潜在的内分泌病。
