Trüeb R M
Dermatologische Klinik, Universitätsspital Zürich, Gloriastr. 31, 8091, Zürich, Switzerland.
Hautarzt. 2010 Jun;61(6):487-95. doi: 10.1007/s00105-009-1890-2.
With respect to the relationship between hormones and hair growth, the role of androgens for androgenetic alopecia (AGA) and hirsutism is best acknowledged. Accordingly, therapeutic strategies that intervene in androgen metabolism have been successfully developed for treatment of these conditions. Clinical observations of hair conditions involving hormones beyond the androgen horizon have determined their role in regulation of hair growth: estrogens, prolactin, thyroid hormone, cortisone, growth hormone (GH), and melatonin. Primary GH resistance is characterized by thin hair, while acromegaly may cause hypertrichosis. Hyperprolactinemia may cause hair loss and hirsutism. Partial synchronization of the hair cycle in anagen during late pregnancy points to an estrogen effect, while aromatase inhibitors cause hair loss. Hair loss in a causal relationship to thyroid disorders is well documented. In contrast to AGA, senescent alopecia affects the hair in a diffuse manner. The question arises, whether the hypothesis that a causal relationship exists between the age-related reduction of circulating hormones and organ function also applies to hair and the aging of hair.
关于激素与头发生长的关系，雄激素在雄激素性脱发（AGA）和多毛症中的作用最为人所知。因此，针对这些病症，已成功开发出干预雄激素代谢的治疗策略。对雄激素范围之外涉及激素的毛发状况的临床观察已确定了它们在调节头发生长中的作用：雌激素、催乳素、甲状腺激素、可的松、生长激素（GH）和褪黑素。原发性GH抵抗的特征是头发稀疏，而肢端肥大症可能导致多毛。高催乳素血症可能导致脱发和多毛。妊娠后期生长期毛囊周期的部分同步表明存在雌激素效应，而芳香化酶抑制剂会导致脱发。甲状腺疾病与脱发之间的因果关系已有充分记录。与AGA不同，老年性脱发以弥漫方式影响头发。问题在于，循环激素和器官功能随年龄增长而降低之间存在因果关系这一假设是否也适用于头发和头发的老化。
