Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Appetite. 2018 Jul 1;126:176-184. doi: 10.1016/j.appet.2018.04.011. Epub 2018 Apr 11.
Binge eating disorder (BED) is an eating disorder involving repeated, intermittent over consumption of food in brief periods of time, usually with no compensatory behaviors. There are few successful treatments and the underlying neural mechanisms remain unclear. In the current study, we hypothesized that voluntary running wheel (RW) activity could reduce binge-like eating behavior in a rat model. Rats were given intermittent (3 times/wk) limited (1hr) access to a high-fat food (Crisco), in addition to continuously available chow. Crisco was available every Mon, Wed, and Fri for 1hr before dark onset. Rats were divided into 2 groups: those with RW access during the first half of the experiment and sedentary during the second half (RW-SED) and those that were sedentary during the first half of the experiment and had RW access during the second half (SED-RW). Crisco intake was significantly less in both groups during the period of time with a RW present. Within the bingeing RW-SED rats, the gene expression of the orexigenic neuropeptides AgRP and NPY were similar to a non-bingeing sedentary control (CON) group, while the expression of the anorexigenic neuropeptide POMC was significantly increased relative to the SED-RW and CON groups. Despite elevated POMC, the rats continued to binge. Additionally, within both groups, the gene expression of the D2R and Oprm1 in the NAc and the VTA were altered suggesting that the reward system was stimulated by both the bingeing behavior and the running wheel activity. Overall, access to a RW and the resulting activity significantly reduced binge-like behavior as well as modulated the effects of binging on brain appetite and reward systems.
暴食症（BED）是一种涉及在短时间内反复、间歇性过度进食的饮食失调症，通常没有补偿性行为。目前的治疗方法效果不佳，其潜在的神经机制仍不清楚。在当前的研究中，我们假设自愿跑步轮（RW）活动可以减少大鼠模型中的暴食样进食行为。除了持续提供的普通食物外，每周 3 次、每次限时 1 小时的高脂肪食物（Crisco）被给予间歇性（限时）进食。在天黑前的 1 小时内，Crisco 可在周一、周三和周五的任何一天食用。大鼠被分为两组：一组在实验的前半段有 RW 活动，后半段则是静坐（RW-SED）；另一组在实验的前半段静坐，后半段则有 RW 活动（SED-RW）。在有 RW 的时间段内，两组大鼠的 Crisco 摄入量都明显减少。在暴食 RW-SED 大鼠中，食欲肽神经肽 AgRP 和 NPY 的基因表达与非暴食静坐对照组（CON）相似，而厌食肽神经肽 POMC 的表达与 SED-RW 和 CON 组相比显著增加。尽管 POMC 水平升高，大鼠仍继续暴食。此外，在两组大鼠中，NAc 和 VTA 中的 D2R 和 Oprm1 基因表达也发生了改变，这表明奖赏系统既受到暴食行为的刺激，也受到跑步轮活动的刺激。总的来说，RW 的使用和由此产生的活动显著减少了暴食样行为，并调节了暴食对大脑食欲和奖赏系统的影响。
