Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, 710061, PR China.
Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, 710061, PR China.
Biomed Pharmacother. 2018 Jul;103:234-239. doi: 10.1016/j.biopha.2018.03.152. Epub 2018 Apr 24.
Leukocyte recruitment to the surface of the endothelium plays a pivotal role in the development of cardiovascular diseases. Bornyl acetate is the main volatile constituent present in numerous conifer oils, which has displayed its anti-oxidant and anti-inflammatory properties in different types of tissues and cells. However, little information regarding the effects of bornyl acetate on vascular endothelial inflammation has been reported before. In the current study, we aimed to investigate the pharmacological roles of bornyl acetate against ox-LDL-induced leukocyte adhesion to the endothelium. Our findings indicate that bornyl acetate ameliorated ox-LDL-induced reduction in cell viability of HUVECs. Additionally, bornyl acetate inhibited the attachment of THP-1 monocytes to HUVECs induced by treatment with ox-LDL through ameliorating the expression of ICAM-1, VCAM-1, and E-selectin. Mechanistically, we found that bornyl acetate could suppress activation of the IκBα/NF-κB signaling pathway. Lastly, our results indicate that bornyl acetate mitigated expression of the pro-inflammatory cytokines TNF-α and IL-1β. Our results suggest the therapeutic potential of bornyl acetate in patients with atherosclerosis.
白细胞向内皮表面的募集在心血管疾病的发展中起着关键作用。乙酸龙脑酯是许多针叶树油中主要的挥发性成分，它在不同类型的组织和细胞中表现出抗氧化和抗炎特性。然而，以前关于乙酸龙脑酯对血管内皮炎症的影响的信息很少。在本研究中，我们旨在研究乙酸龙脑酯对 ox-LDL 诱导的白细胞与内皮细胞黏附的药理学作用。我们的研究结果表明，乙酸龙脑酯改善了 ox-LDL 诱导的 HUVECs 细胞活力降低。此外，乙酸龙脑酯通过改善 ICAM-1、VCAM-1 和 E-选择素的表达来抑制 ox-LDL 处理诱导的 THP-1 单核细胞与 HUVECs 的附着。在机制上，我们发现乙酸龙脑酯可以抑制 IκBα/NF-κB 信号通路的激活。最后，我们的结果表明，乙酸龙脑酯减轻了促炎细胞因子 TNF-α 和 IL-1β 的表达。我们的研究结果表明，乙酸龙脑酯在动脉粥样硬化患者中有治疗潜力。
