Reductive Elimination Leading to C-C Bond Formation in Gold(III) Complexes: A Mechanistic and Computational Study.

The factors affecting the rates of reductive C-C cross-coupling reactions in gold(III) aryls were studied by using complexes that allow easy access to a series of electronically modified aryl ligands, as well as to gold methyl and vinyl complexes, by using the pincer compounds [(C^N^C)AuR] (R=C F , CH=CMe , Me and p-C H X, where X=OMe, F, H, tBu, Cl, CF , or NO ) as starting materials (C^N^C=2,6-(4'-tBuC H ) pyridine dianion). Protodeauration followed by addition of one equivalent SMe leads to the quantitative generation of the thioether complexes [(C^N-CH)AuR(SMe )] . Upon addition of a second SMe pyridine is displaced, which triggers the reductive aryl-R elimination. The rates for these cross-couplings increase in the sequence k(vinyl)>k(aryl)≫k(C F )>k(Me). Vinyl-aryl coupling is particularly fast, 1.15×10  L mol  s at 221 K, whereas both C F and Me couplings encountered higher barriers for the C-C bond forming step. The use of P(p-tol) in place of SMe greatly accelerates the C-C couplings. Computational modelling shows that in the C^N-bonded compounds displacement of N by a donor L is required before the aryl ligands can adopt a conformation suitable for C-C bond formation, so that elimination takes place from a four-coordinate intermediate. The C-C bond formation is the rate-limiting step. In the non-chelating case, reductive C(sp )-C(sp ) elimination from three-coordinate ions [(Ar )(Ar )AuL] is almost barrier-free, particularly if L=phosphine.