Liu Chunli, Lv Han, Jiang Tao, Xie Jing, He Lu, Wang Guopeng, Liu Jiao, Wang Zhenchang, Gong Shusheng
Department of Otolaryngology Head and Neck, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Department of Otolaryngology, The Affiliated Hospital of Chengde Medical College, Hebei 067000, China.
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Am J Otolaryngol. 2018 Jul-Aug;39(4):401-409. doi: 10.1016/j.amjoto.2018.04.002. Epub 2018 Apr 3.
We intend to assess the effectiveness of a novel tinnitus treatment therapy, the Cochleural Alternating Acoustic Beam Therapy (CAABT) using the psychoacoustic measures, the questionnaires and rs-fMRI.
In this study, we enrolled 11 older than 18 years old Chinese patients with normal hearing who had unilateral, chronic (longer than 6 months), sensorineural tinnitus, of frequencies between 125-8000 Hz, and an average loudness of 31 dB. The patients underwent the treatment with the CAABT method for 12 weeks and the outcomes were evaluated with tinnitus questionnaire scores, a set of psychoacoustic measures, and rs-fMRI testing before treatment and at 3 months. This was an earlier study of the controlled randomized clinical trial which was registered with ClinicalTrials.gov, number NCT02774122.
Almost all the patients reported reduced tinnitus annoyance after the three-month treatment. The THI and VAS scores showed decreased tinnitus severity. The rs-fMRI results indicated that the right middle frontal gyrus and the right superior temporal gyrus displayed noticeable decreases of the ReHo values for the subjects between the before and after treatment, supporting the clinical evidence of significant tinnitus reduction.
The therapy seemed effective in patients of varying severities, and no side effects were observed in this trial. The CAABT can be an alternative for those who are suitable for sound therapy once a large scale of and better controlled clinical studies have validated the findings of this experiment.
我们旨在使用心理声学测量、问卷调查和静息态功能磁共振成像（rs-fMRI）评估一种新型耳鸣治疗方法——耳蜗交替声束疗法（CAABT）的有效性。
在本研究中，我们招募了11名年龄大于18岁、听力正常的中国患者，他们患有单侧慢性（超过6个月）感音神经性耳鸣，频率在125 - 8000赫兹之间，平均响度为31分贝。患者采用CAABT方法进行治疗，为期12周，并在治疗前和3个月时通过耳鸣问卷评分、一系列心理声学测量和rs-fMRI测试来评估结果。这是一项早期的对照随机临床试验研究，已在ClinicalTrials.gov上注册，编号为NCT02774122。
几乎所有患者在三个月的治疗后都报告耳鸣烦恼减轻。耳鸣残疾评定量表（THI）和视觉模拟量表（VAS）评分显示耳鸣严重程度降低。rs-fMRI结果表明，治疗前后，受试者右侧额中回和右侧颞上回的局部一致性（ReHo）值显著降低，支持了耳鸣显著减轻的临床证据。
该疗法对不同严重程度的患者似乎都有效，且在本试验中未观察到副作用。一旦大规模且控制更好的临床研究验证了本实验的结果，CAABT对于那些适合声音疗法的患者来说可以成为一种选择。
