Tishler M, Caspi D, Gazit E, Yaron M
Department of Rheumatology, Tel Aviv Medical Center, Israel.
Ann Rheum Dis. 1988 Mar;47(3):215-7. doi: 10.1136/ard.47.3.215.
Seventy-four Israeli patients with rheumatoid arthritis (RA) were studied for possible association between HLA antigens and adverse reactions to gold treatment (aurothioglucose). HLA-B35 was significantly increased in patients who developed gold induced mucocutaneous lesions. These results are in accord with earlier reports, despite the different genetic background of the Israeli RA population and the different type of gold compound used.
对74名患有类风湿性关节炎(RA)的以色列患者进行了研究,以探讨HLA抗原与金制剂(硫代葡萄糖金)治疗不良反应之间的可能关联。发生金诱导的皮肤黏膜病变的患者中,HLA - B35显著增加。尽管以色列类风湿性关节炎患者群体的遗传背景不同,且使用的金化合物类型不同,但这些结果与早期报告一致。