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以色列类风湿关节炎患者接受金治疗时HLA - B35与皮肤黏膜病变的关联

Association of HLA-B35 with mucocutaneous lesions in Israeli patients with rheumatoid arthritis receiving gold treatment.

作者信息

Tishler M, Caspi D, Gazit E, Yaron M

机构信息

Department of Rheumatology, Tel Aviv Medical Center, Israel.

出版信息

Ann Rheum Dis. 1988 Mar;47(3):215-7. doi: 10.1136/ard.47.3.215.

Abstract

Seventy-four Israeli patients with rheumatoid arthritis (RA) were studied for possible association between HLA antigens and adverse reactions to gold treatment (aurothioglucose). HLA-B35 was significantly increased in patients who developed gold induced mucocutaneous lesions. These results are in accord with earlier reports, despite the different genetic background of the Israeli RA population and the different type of gold compound used.

摘要

对74名患有类风湿性关节炎(RA)的以色列患者进行了研究,以探讨HLA抗原与金制剂(硫代葡萄糖金)治疗不良反应之间的可能关联。发生金诱导的皮肤黏膜病变的患者中,HLA - B35显著增加。尽管以色列类风湿性关节炎患者群体的遗传背景不同,且使用的金化合物类型不同,但这些结果与早期报告一致。

相似文献

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HLA-Bw35 and mucocutaneous toxicity in rheumatoid arthritis patients treated with gold.
Arthritis Rheum. 1986 Feb;29(2):303. doi: 10.1002/art.1780290223.

本文引用的文献

7
A study of HLA antigen association in localized and generalized granuloma annulare.
Br J Dermatol. 1986 Sep;115(3):329-33. doi: 10.1111/j.1365-2133.1986.tb05747.x.

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