HLA-Aw31和HLA-DR1与成人类风湿性关节炎的关联。
Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.
作者信息
Schiff B, Mizrachi Y, Orgad S, Yaron M, Gazit E
出版信息
Ann Rheum Dis. 1982 Aug;41(4):403-4. doi: 10.1136/ard.41.4.403.
Abstract
Forty-nine Israeli Jewish patients with rheumatoid arthritis (RA) were studied for their HLA A, B, C, DR antigen frequency. A significant increase in HLA Aw31 and HLA DR1 was observed (p less than 5.10(-5) and p less than 5.10(-3) respectively). 45% of Aw31 positive patients were sero-negative for rheumatoid factor, while most HLA DR1 positive individuals were seropositive. DR5 was found to be significantly decreased (p less than 5.10(-4)). Contrary to previous reports, DRw4 was found to be within the range of antigen frequency of the controls (34.7% vs. 32%). It is suggested that in our population of patients Aw31 and DR1 and not DR4 are highly associated with adult onset of RA.
摘要
对49名患有类风湿性关节炎（RA）的以色列犹太患者进行了HLA A、B、C、DR抗原频率研究。观察到HLA Aw31和HLA DR1显著增加（分别为p<5×10⁻⁵和p<5×10⁻³）。45%的Aw31阳性患者类风湿因子血清学阴性，而大多数HLA DR1阳性个体血清学阳性。发现DR5显著降低（p<5×10⁻⁴）。与先前报告相反，发现DRw4在对照组抗原频率范围内（34.7%对32%）。有人提出，在我们的患者群体中，Aw31和DR1而非DR4与成人RA发病高度相关。
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本文引用的文献
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