用微生物疏水性蛋白包被：开发智能药物纳米粒子的新方法。
Coating with Microbial Hydrophobins: A Novel Approach to Develop Smart Drug Nanoparticles.
机构信息
Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001, India.
Centre of Excellence in Materials Science (Nanomaterials), Z.H. College of Engineering & Technology, Aligarh Muslim University, Aligarh 202002, India; Current address: TERI-Deakin Nanobiotechnology Centre, TERI Gram, The Energy and Resources Institute, Gual Pahari, Gurugram-Faridabad Road, Gurugram 122 001, Haryana, India.
出版信息
Trends Biotechnol. 2018 Nov;36(11):1103-1106. doi: 10.1016/j.tibtech.2018.03.006. Epub 2018 Apr 11.
Microbial hydrophobin (MH)-based surface coating is emerging as a novel protein engineering approach for drug nanoparticles to enhance the solubility and stability of therapeutic agents. These hydrophobins are amphiphilic proteins that can form self-assembled monolayers on hydrophobic materials and can coat nanoparticles for efficient drug delivery.
微生物疏水蛋白（MH）基表面涂层作为一种新型的蛋白质工程方法，可用于药物纳米颗粒，以提高治疗剂的溶解度和稳定性。这些疏水蛋白是两亲性蛋白质，可在疏水性材料上形成自组装单层，并可用于纳米颗粒涂层，以实现有效的药物传递。
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