巨噬细胞：人迹罕至之路，改变癌症治疗策略。
Macrophages: The Road Less Traveled, Changing Anticancer Therapy.
机构信息
Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
出版信息
Trends Mol Med. 2018 May;24(5):472-489. doi: 10.1016/j.molmed.2018.03.006. Epub 2018 Apr 11.
Abstract
Macrophages are present in all vertebrate tissues and have emerged as multifarious cells with complex roles in development, tissue homeostasis, and disease. Macrophages are a major constituent of the tumor microenvironment, where they either promote or inhibit tumorigenesis and metastasis depending on their state. Successful preclinical strategies to target macrophages for anticancer therapy are now being evaluated in the clinic and provide proof of concept that targeting macrophages may enhance current therapies; however, clinical success has been limited. This review discusses the promise of targeting macrophages for anticancer therapy, yet highlights how much is unknown regarding their ontogeny, regulation, and tissue-specific diversity. Further work might identify subsets of macrophages within different tissues, which could reveal novel therapeutic opportunities for anticancer therapy.
摘要
巨噬细胞存在于所有脊椎动物组织中，已成为具有复杂功能的多能细胞，在发育、组织稳态和疾病中发挥作用。巨噬细胞是肿瘤微环境的主要组成部分，它们根据状态促进或抑制肿瘤发生和转移。目前正在临床中评估针对巨噬细胞的抗癌治疗的成功临床前策略，并提供了针对巨噬细胞可能增强现有疗法的概念验证；然而，临床成功是有限的。这篇综述讨论了针对巨噬细胞进行抗癌治疗的前景，但强调了关于它们的发生、调节和组织特异性多样性的许多未知。进一步的研究可能会在不同组织中确定巨噬细胞的亚群，这可能为抗癌治疗带来新的治疗机会。
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