Carl Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Bioresour Technol. 2018 Jul;260:380-394. doi: 10.1016/j.biortech.2018.04.013. Epub 2018 Apr 7.
The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. This review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.
大量针对木质纤维素生物燃料的研究工作为代谢工程生成了丰富的有价值的知识和技术。特别是，这些投资极大地提高了工程酵母酿酒酵母利用木质纤维素糖的能力，使酵母能够同时同化多种碳源，并通过引入异源代谢途径生产各种有附加值的产品。虽然纤维素糖转化为大容量低价值生物燃料的微生物转化目前在经济上不可行，但仍有可能生产其他有附加值的化学品，因为纤维素糖代谢的调控与葡萄糖代谢有很大的不同。本综述重点介绍了利用工程酵母将木质纤维素糖转化为各种非乙醇附加值产品的最新进展。
